RAB7A Antikörper (AA 101-207) (Alexa Fluor 488)

Produktnummer ABIN912733

Produktdetails anti-RAB7A Antikörper (Alexa Fluor 488)

Target: RAB7A (RAB7A, Member RAS Oncogene Family (RAB7A))

Bindungsspezifität: AA 101-207

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RAB7A Antikörper ist konjugiert mit Alexa Fluor 488

Applikation: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc))

Kreuzreaktivität: Human, Maus

Homologie: Rat

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human RAB7

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: FCM 1:20-100
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Referenzen für anti-RAB7A Antikörper (Alexa Fluor 488) (ABIN912733)

Pohar, Lainšček, Ivičak-Kocjan, Cajnko, Jerala, Benčina: "Short single-stranded DNA degradation products augment the activation of Toll-like receptor 9." in: Nature communications, Vol. 8, pp. 15363, (2018) (PubMed).

Details zu RAB7A

Target: RAB7A (RAB7A, Member RAS Oncogene Family (RAB7A))

Andere Bezeichnung: RAB7 (RAB7A Produkte)

Synonyme: RAB5 antikoerper, PRO2706 antikoerper, RAB7 antikoerper, Rab7 antikoerper, rab7 antikoerper, pro2706 antikoerper, RAB7A antikoerper, LOC100231734 antikoerper, ARABIDOPSIS RAB GTPASE HOMOLOG G2 antikoerper, ATRAB7A antikoerper, ATRABG2 antikoerper, F7D8.20 antikoerper, F7D8_20 antikoerper, RAB GTPase homolog 7A antikoerper, DDBDRAFT_0190210 antikoerper, DDBDRAFT_0191507 antikoerper, DDB_0190210 antikoerper, DDB_0191507 antikoerper, Rab7a antikoerper, rab-7 antikoerper, zgc:64058 antikoerper, RAB5A, member RAS oncogene family antikoerper, RAB7A, member RAS oncogene family antikoerper, RAB7A, member RAS oncogene family L homeolog antikoerper, rab7A protein antikoerper, RAB GTPase homolog 7A antikoerper, Rab GTPase antikoerper, ras-related protein rab-7a antikoerper, RAB7, member RAS oncogene family antikoerper, RAB5A antikoerper, RAB7A antikoerper, Rab7a antikoerper, rab7a.L antikoerper, rab7a antikoerper, rab7A antikoerper, Rab7 antikoerper, rab7 antikoerper

Hintergrund:

Synonyms: RAB7, PRO276, Ras-related protein Rab-7a, RAB7A

Background: Key regulator in endo-lysosomal trafficking. Governs early-to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades. Plays a central role, not only in endosomal traffic, but also in many other cellular and physiological events, such as growth-factor-mediated cell signaling, nutrient-transportor mediated nutrient uptake, neurotrophin transport in the axons of neurons and lipid metabolism. Also involved in regulation of some specialized endosomal membrane trafficking, such as maturation of melanosomes, pathogen-induced phagosomes (or vacuoles) and autophagosomes. Plays a role in the maturation and acidification of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays a role in the fusion of phagosomes with lysosomes. Plays important roles in microbial pathogen infection and survival, as well as in participating in the life cycle of viruses. Microbial pathogens possess survival strategies governed by RAB7A, sometimes by employing RAB7A function (e.g. Salmonella) and sometimes by excluding RAB7A function (e.g. Mycobacterium). In concert with RAC1, plays a role in regulating the formation of RBs (ruffled borders) in osteoclasts. Controls the endosomal trafficking and neurite outgrowth signaling of NTRK1/TRKA. Regulates the endocytic trafficking of the EGF-EGFR complex by regulating its lysosomal degradation.

Gen-ID: 7879

UniProt: P51149

Pathways: EGFR Signaling Pathway, Maintenance of Protein Location, SARS-CoV-2 Protein Interaktom