BRK1 Antikörper (AA 31-75) (Alexa Fluor 647)

Produktnummer ABIN900641

Produktdetails anti-BRK1 Antikörper (Alexa Fluor 647)

Target: BRK1 (BRICK1, SCAR/WAVE Actin-Nucleating Complex Subunit (BRK1))

Bindungsspezifität: AA 31-75

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser BRK1 Antikörper ist konjugiert mit Alexa Fluor 647

Applikation: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Homologie: Human,Mouse,Rat,Cow,Pig

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human hHBrk1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu BRK1

Target: BRK1 (BRICK1, SCAR/WAVE Actin-Nucleating Complex Subunit (BRK1))

Andere Bezeichnung: hHBrk1 (BRK1 Produkte)

Synonyme: brk1 antikoerper, C22H3orf10 antikoerper, brick1 antikoerper, c3orf10 antikoerper, C3orf10 antikoerper, MDS027 antikoerper, hHBrk1 antikoerper, 6720456B07Rik antikoerper, AW011779 antikoerper, ATBRK1 antikoerper, BRICK1 antikoerper, HSPC300 antikoerper, T9I22.8 antikoerper, T9I22_8 antikoerper, BRICK1, SCAR/WAVE actin-nucleating complex subunit antikoerper, BRICK1, SCAR/WAVE actin nucleating complex subunit antikoerper, brick 1 antikoerper, BRICK1, SCAR/WAVE actin-nucleating complex subunit S homeolog antikoerper, BRICK1 antikoerper, brk1 antikoerper, BRK1 antikoerper, Brk1 antikoerper, brk1.S antikoerper

Hintergrund:

Synonyms: Brk1-like, C3orf10 chromosome 3 open reading frame 10, C3ORF10 GENE, Chromosome 3 open reading frame 10, hHBrk1, HSPC300, MDS027, Probable protein BRICK1, BRK1_HUMAN.

Background: HSPC300 (hematopoietic stem cell protein 300) is also known as probable protein BRICK1 or C3orf10 (chromosome 3 open reading frame 10) and is a 75 amino acid protein that is expressed as two isoforms and localizes to both the cytoplasm and the cytoskeleton. HSPC300 is thought to regulate cytoskeletal organization and Actin polymerization. Free HSPC300 exists as homotrimers prior to its incorporation into the WAVE complex. The WAVE complex includes five proteins, one of which is HSPC300, that regulate the ARC (Arp2/3 complex) which is responsible for Actin nucleation and is Rac 1-dependent. Because HSPC300 is a highly conserved subunit of the WAVE complex across many species, it is thought to have the same or similar functions in many different organisms. In Drosophila, the WAVE/ARC pathway may affect the development of the nervous system. HSPC300 is thought to localize to axons of the central nervous system of Drosophila embryos and thus may also be involved in axonogenesis. In addition, HSPC300 is thought to be necessary for synaptic morphogenesis by motoneurons. In mice, the knockout of the WAVE complex leads to learning and memory defects, and it is therefore hypothesized that HSPC300 may also be involved in cognitive functions. Genetic depletion of HSPC300 results in cytoskeletal abnormalities and prevents cytokinesis of cells, suggesting that decreased levels of HSPC300 may be associated with tumor suppression.

Gen-ID: 55845

Pathways: RTK Signalweg