ADAMTS8 Antikörper (AA 541-640) (Alexa Fluor 350)

Produktnummer ABIN881373

Produktdetails anti-ADAMTS8 Antikörper (Alexa Fluor 350)

Target: ADAMTS8 (ADAM Metallopeptidase with thrombospondin Type 1 Motif, 8 (ADAMTS8))

Bindungsspezifität: AA 541-640

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ADAMTS8 Antikörper ist konjugiert mit Alexa Fluor 350

Applikation: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Homologie: Human,Mouse,Rat,Dog,Pig,Horse,Chicken

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human ADAMTS8

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu ADAMTS8

Target: ADAMTS8 (ADAM Metallopeptidase with thrombospondin Type 1 Motif, 8 (ADAMTS8))

Andere Bezeichnung: ADAMTS8 (ADAMTS8 Produkte)

Synonyme: ADAMTS8 antikoerper, METH-2 antikoerper, METH2 antikoerper, ADAM-TS8 antikoerper, ADAM metallopeptidase with thrombospondin type 1 motif 8 antikoerper, a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 8 antikoerper, ADAM metallopeptidase with thrombospondin type 1 motif, 8 antikoerper, ADAMTS8 antikoerper, adamts8 antikoerper, Adamts8 antikoerper

Hintergrund:

Synonyms: A disintegrin and metalloproteinase with thrombospondin mots 8, ADAMTS 8, METH 2, METH 8, METH8, A disintegrin like and metalloprotease reprolysin type with thrombospondin type 1 mot 8, A disintegrin like and metalloprotease with thrombospondin type 1 mot 8, ADAM metallopeptidase with thrombospondin type 1 mot 8, ADAM TS 8, ADAM TS8, METH2, ATS8_HUMAN.

Background: ADAMTS proteases are secreted enzymes containing a prometalloprotease domain of the reprolysin type. The ADAMTS proteases function in processing of procollagens and von Willebrand factor as well as catabolism of aggrecan, versican and brevican. They have been demonstrated to have important roles in connective tissue organization, coagulation, inflammation, arthritis, angiogenesis and cell migration.A member of the metalloproteinase family containing disintegrin like domains (ADAMs), the function of ADAMTS8 is still poorly understood. ADAMTS8 contains the canonical HExxHxxxxxH zinc metalloproteinase motif, and has been shown to be proteolytically active on a range of substrates. ADAMTS8 is inhibited by the endogenous MMP inhibitors, TIMP1, 2, 3 and 4, but most efficiently by TIMP3. In addition to the metalloprotease domain, ADAMTS8 has a propeptide domain, a Prohormone Convertase (PC, furin) cleavage site, a cysteine rich domain and thrombospondin 1 like domains.

Gen-ID: 11095