NET1 Antikörper (AA 501-596)

Produktnummer ABIN873108

Produktdetails anti-NET1 Antikörper

Target: NET1 (Neuroepithelial Cell Transforming 1 (NET1))

Bindungsspezifität: AA 501-596

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NET1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Kreuzreaktivität: Human, Maus

Homologie: Rat,Dog,Cow,Horse,Chicken

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human NET1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Details zu NET1

Target: NET1 (Neuroepithelial Cell Transforming 1 (NET1))

Andere Bezeichnung: Net1 (NET1 Produkte)

Synonyme: arhgef8 antikoerper, net1a antikoerper, xNET1 antikoerper, DKFZp459I0423 antikoerper, NET1 antikoerper, ARHGEF8 antikoerper, NET1A antikoerper, 0610025H04Rik antikoerper, 9530071N24Rik antikoerper, AI604373 antikoerper, AU015857 antikoerper, Net1a antikoerper, mNET1 antikoerper, wu:fb13g03 antikoerper, wu:fb25c11 antikoerper, zgc:92121 antikoerper, neuroepithelial cell transforming 1 antikoerper, neuroepithelial cell-transforming gene 1 protein antikoerper, neuroepithelial cell transforming 1 L homeolog antikoerper, neuroepithelial cell transforming gene 1 antikoerper, net1 antikoerper, EDI_348570 antikoerper, NET1 antikoerper, Net1 antikoerper, net1.L antikoerper

Hintergrund:

Synonyms: NAT1, NET, NET, NET1, Norepinephrine transporter, SLC6A2, SLC6A5, SLC6A5, Sodium dependent noradrenaline transporter, Solute carrier family 6 neurotransmitter transporter norepinephrine member 5, Solute carrier family 6 member 2, Solute carrier family 6 member 2.

Background: Catecholamine, a term used for the hormone adrenaline and its sequentially hydroxylated form noradrenaline, is involved in fight or flight responses. Noradrenaline is released from the post ganglionic sympathetic nerve endings and exerts its effects locally in the immediate vicinity of its release. In the CNS, noradrenaline is involved in a number of physiological responses including mood, sleep regulation, alertness and arousal, both cognitive and non-cognitive expression of behaviors, and control of the endocrine and autonomic nervous systems. Peripherally, noradrenaline is present in sympathetic nerve endings and has full control of the sympathetic nervous system. Noradrenaline released from pre-synaptic nerve terminals is reabsorbed (70-90 % ) by noradrenaline transporters and its biological effects are terminated. The noradrenaline transport via noradrenaline transporters is an active, Na+/Cl- dependent transport process mediated by noradrenaline transporters. Noradrenaline transporters constitute the primary mechanism for inactivation of synaptically released noradrenaline, are targets for multiple antidepressants and psychostimulants, and are deficient in affective and autonomic disorders. In rat brain, noradrenaline transporter is expressed in noradrenergic neuronal somata, axons and dendrites, and hippocampus and cortex, but is absent from epinephrine- and dopamine-containing neurons. At least 13 genetic variations have been reported in the noradrenaline transporter protein that affect noradrenaline re-uptake and concentrations in cerebrospinal fluid in humans. The association between these genetic variations in noradrenaline transporters and several psychiatric and cardiovascular disorders is just emerging. Recently, a single amino acid mutation (hNET-A457P) showed deficiency in noradrenaline transport in an orthostatic intolerance patient.

Gen-ID: 10276

Pathways: Neurotrophin Signalübertragung