TNFRSF21 Antikörper (AA 101-200)

Produktnummer ABIN873098

Produktdetails anti-TNFRSF21 Antikörper

Target: TNFRSF21 (Tumor Necrosis Factor Receptor Superfamily, Member 21 (TNFRSF21))

Bindungsspezifität: AA 101-200

Reaktivität: Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TNFRSF21 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Kreuzreaktivität: Maus, Ratte

Homologie: Human,Dog,Cow,Horse,Chicken,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human DR6

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Referenzen für anti-TNFRSF21 Antikörper (ABIN873098)

Strilic, Yang, Albarrán-Juárez, Wachsmuth, Han, Müller, Pasparakis, Offermanns: "Tumour-cell-induced endothelial cell necroptosis via death receptor 6 promotes metastasis." in: Nature, Vol. 536, Issue 7615, pp. 215-8, (2016) (PubMed).

Details zu TNFRSF21

Target: TNFRSF21 (Tumor Necrosis Factor Receptor Superfamily, Member 21 (TNFRSF21))

Andere Bezeichnung: DR6 (TNFRSF21 Produkte)

Synonyme: TNFRSF21 antikoerper, tnfrsf21 antikoerper, MGC146356 antikoerper, BM-018 antikoerper, CD358 antikoerper, DR6 antikoerper, AA959878 antikoerper, R74815 antikoerper, TR7 antikoerper, dr6 antikoerper, im:6795346 antikoerper, wu:fa55e01 antikoerper, wu:fb02e11 antikoerper, wu:fc29a09 antikoerper, wu:fi27h08 antikoerper, TNF receptor superfamily member 21 antikoerper, tumor necrosis factor receptor superfamily member 21 antikoerper, tumor necrosis factor receptor superfamily, member 21 antikoerper, TNFRSF21 antikoerper, tnfrsf21 antikoerper, Tnfrsf21 antikoerper

Hintergrund:

Synonyms: DR6, CD358, BM-018, Tumor necrosis factor receptor superfamily member 21, Death receptor 6, TNFRSF21, UNQ437/PRO868

Background: Promotes apoptosis, possibly via a pathway that involves the activation of NF-kappa-B. Can also promote apoptosis mediated by BAX and by the release of cytochrome c from the mitochondria into the cytoplasm. Plays a role in neuronal apoptosis, including apoptosis in response to amyloid peptides derived from APP, and is required for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP). N-APP binds TNFRSF21, this triggers caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6). Negatively regulates oligodendrocyte survival, maturation and myelination. Plays a role in signaling cascades triggered by stimulation of T-cell receptors, in the adaptive immune response and in the regulation of T-cell differentiation and proliferation. Negatively regulates T-cell responses and the release of cytokines such as IL4, IL5, IL10, IL13 and IFNG by Th2 cells. Negatively regulates the production of IgG, IgM and IgM in response to antigens. May inhibit the activation of JNK in response to T-cell stimulation.

Gen-ID: 27242

UniProt: O75509

Pathways: Regulation of Lipid Metabolism by PPARalpha