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PKC beta Antikörper (pThr641)

PRKCB Reaktivität: Human, Ratte, Maus WB, IHC, IF Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN871421
  • Target Alle PKC beta (PRKCB) Antikörper anzeigen
    PKC beta (PRKCB) (Protein Kinase C, beta (PRKCB))
    Bindungsspezifität
    • 16
    • 16
    • 15
    • 14
    • 13
    • 12
    • 8
    • 7
    • 7
    • 7
    • 6
    • 6
    • 5
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pThr641
    Reaktivität
    • 128
    • 98
    • 93
    • 15
    • 8
    • 6
    • 5
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Ratte, Maus
    Wirt
    • 147
    • 5
    • 3
    • 2
    • 1
    Kaninchen
    Klonalität
    • 142
    • 16
    Polyklonal
    Konjugat
    • 66
    • 15
    • 11
    • 8
    • 7
    • 6
    • 6
    • 6
    • 6
    • 6
    • 6
    • 5
    • 2
    • 2
    • 2
    • 2
    • 2
    Dieser PKC beta Antikörper ist unkonjugiert
    Applikation
    • 124
    • 69
    • 53
    • 31
    • 27
    • 26
    • 21
    • 16
    • 9
    • 8
    • 7
    • 2
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
    Spezifität
    The antibody detects endogenous levels of PKCb only when phosphorylated at threonine 641.
    Aufreinigung
    Affinity purified
    Immunogen
    Peptide sequence around phosphorylation site of pThr641 (E-L-T (p) -P-T) derived from Human PKCb Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates.
    Top Product
    Discover our top product PRKCB Primärantikörper
  • Applikationshinweise
    Western blotting: 1:500-1:1000
    Immunohistochemistry: 1:50-1:100
    Immunofluorescence: 1:100-1:200
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
  • Losso, Truax, Richard: "trans-resveratrol inhibits hyperglycemia-induced inflammation and connexin downregulation in retinal pigment epithelial cells." in: Journal of agricultural and food chemistry, Vol. 58, Issue 14, pp. 8246-52, (2010) (PubMed).

  • Target
    PKC beta (PRKCB) (Protein Kinase C, beta (PRKCB))
    Andere Bezeichnung
    PKCbeta (PRKCB Produkte)
    Synonyme
    PKC-beta antikoerper, PKCB antikoerper, PRKCB1 antikoerper, PRKCB2 antikoerper, A130082F03Rik antikoerper, PKC-Beta antikoerper, Pkcb antikoerper, Prkcb1 antikoerper, Prkcb2 antikoerper, PKC-B antikoerper, Prkcb antikoerper, prkcb1 antikoerper, zgc:63591 antikoerper, PKC antikoerper, PRKCB_tv2 antikoerper, Pkc53E antikoerper, prkcb1l antikoerper, zgc:64063 antikoerper, protein kinase C beta antikoerper, protein kinase C, beta antikoerper, protein kinase C, beta b antikoerper, protein kinase C, beta a antikoerper, PRKCB antikoerper, Prkcb antikoerper, prkcbb antikoerper, prkcba antikoerper
    Hintergrund
    Calcium-activated and phospholipid-dependent serine/threonine-protein kinase involved in various processes such as regulation of the B-cell receptor (BCR) signalosome, apoptosis and transcription regulation. Plays a key role in B-cell activation and function by regulating BCR-induced NF-kappa-B activation and B-cell suvival. Required for recruitment and activation of the IKK kinase to lipid rafts and mediates phosphorylation of CARD11/CARMA1 at 'Ser-559', 'Ser-644' and 'Ser-652', leading to activate the NF-kappa-B signaling. Involved in apoptosis following oxidative damage: in case of oxidative conditions, specifically phosphorylates 'Ser-36' of isoform p66Shc of SHC1, leading to mitochondrial accumulation of p66Shc, where p66Shc acts as a reactive oxygen species producer. Acts as a coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and specifically mediating phosphorylation of 'Thr-6' of histone H3 (H3T6ph), a specific tag for epigenetic transcriptional activation that prevents demethylation of histone H3 'Lys-4' (H3K4me) by LSD1/KDM1A. Also involved in triglyceride homeostasis. Serves as the receptor for phorbol esters, a class of tumor promoters.
    Molekulargewicht
    82 kDa
    Gen-ID
    5579
    NCBI Accession
    NP_002729
    UniProt
    P05771
    Pathways
    WNT Signalweg, T-Zell Rezeptor Signalweg, Thyroid Hormone Synthesis, Nuclear Hormone Receptor Binding, Chromatin Binding, Myometrial Relaxation and Contraction, VEGF Signaling, Unfolded Protein Response, BCR Signaling
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