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ISR-beta Antikörper (pTyr1185)

ISR-beta Reaktivität: Human, Ratte, Maus WB, IF (cc), IF (p), ELISA, IHC (fro) Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN802293
  • Target Alle ISR-beta Antikörper anzeigen
    ISR-beta (Insulin Receptor beta (ISR-beta))
    Bindungsspezifität
    • 16
    • 16
    • 16
    • 14
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pTyr1185
    Reaktivität
    • 79
    • 74
    • 59
    • 5
    • 5
    • 4
    • 4
    • 1
    • 1
    • 1
    Human, Ratte, Maus
    Wirt
    • 77
    • 2
    Kaninchen
    Klonalität
    • 77
    • 2
    Polyklonal
    Konjugat
    • 10
    • 5
    • 5
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    Dieser ISR-beta Antikörper ist unkonjugiert
    Applikation
    • 59
    • 50
    • 38
    • 38
    • 14
    • 9
    • 8
    • 5
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro))
    Kreuzreaktivität
    Human, Maus, Ratte
    Homologie
    Dog,Cow,Pig,Chicken,Rabbit
    Aufreinigung
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic phosphopeptide derived from human INSR around the phosphorylation site of Tyr1185 [DI(p-Y)ET]
    Isotyp
    IgG
    Top Product
    Discover our top product ISR-beta Primärantikörper
  • Applikationshinweise
    WB 1:300-5000
    ELISA 1:500-1000
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Haltbarkeit
    12 months
  • Tsuchiya, Kanno, Nishizaki: "Stearic acid serves as a potent inhibitor of protein tyrosine phosphatase 1B." in: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, Vol. 32, Issue 5, pp. 1451-9, (2014) (PubMed).

  • Target
    ISR-beta (Insulin Receptor beta (ISR-beta))
    Andere Bezeichnung
    Insulin Receptor Beta (ISR-beta Produkte)
    Synonyme
    CD220 antikoerper, HHF5 antikoerper, 4932439J01Rik antikoerper, D630014A15Rik antikoerper, IR antikoerper, IR-A antikoerper, IR-B antikoerper, insulin receptor antikoerper, INSR antikoerper, Insr antikoerper
    Hintergrund

    Synonyms: HHF5, CD22, Insulin receptor, IR, INSR

    Background: The human insulin receptor is a heterotetrameric membrane glycoprotein consisting of disulfide linked subunits in a beta-alpha-alpha-beta configuration. The beta subunit (95 kDa) possesses a single transmembrane domain, whereas the alpha subunit (135 kDa) is completely extracellular. The insulin receptor exhibits receptor tyrosine kinase (RTK) activity. RTKs are single pass transmembrane receptors that possess intrinsic cytoplasmic enzymatic activity, catalyzing the transfer of the gamma phosphate of ATP to tyrosine residues in protein substrates. RTKs are essential components of signal transduction pathways that affect cell proliferation, differentiation, migration and metabolism.Included in this large protein family are the insulin receptor and the receptors for growth factors such as epidermal growth factor, fibroblast growth factor and vascular endothelial growth factor. Receptor activation occurs through ligand binding, which facilitates receptor dimerization and autophosphorylation of specific tyrosine residues in the cytoplasmic portion. The interaction of insulin with the alpha subunit of the insulin receptor activates the protein tyrosine kinase of the beta subunit, which then undergoes an autophosphorylation that increases its tyrosine kinase activity. Three adapter proteins, IRS1, IRS2 and Shc, become phosphorylated on tyrosine residues following insulin receptor activation. These three phosphorylated proteins then interact with SH2 domain containing signaling proteins.

    Gen-ID
    3643
    UniProt
    P06213
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