cb629 antikoerper, DrZIP1 antikoerper, sb:cb629 antikoerper, zgc:111852 antikoerper, frzip1p antikoerper, zip1 antikoerper, zirtl antikoerper, ZIP1 antikoerper, ZIRTL antikoerper, Zip1 antikoerper, Zirtl antikoerper, solute carrier family 39 (zinc transporter), member 1 antikoerper, solute carrier family 39 member 1 antikoerper, solute carrier family 39 member 1 L homeolog antikoerper, slc39a1 antikoerper, Slc39a1 antikoerper, SLC39A1 antikoerper, slc39a1.L antikoerper
Hintergrund
ZIP1, also known as ZIRTL (zinc-iron regulated transporter-like), is the first mammalian member of a family of divalent ion transporters. Zinc is an essential ion for cells and plays significant roles in the growth, development, and differentiation. ZIP1 expression is markedly downregulated in a number of cancerous tissues and is thought to function as a tumor suppressor gene in prostate cancer. More recent studies have shown that overexpression of ZIP1 and concomitant increased levels of intracellular zinc in PC-3 cells cause a significant inhibition of NF-kappaB, leading to down-regulation of the antiapoptotic protein Bcl-2, Bcl-XL, and the apoptosis inhibitor XIAP, reducing the malignant potential of prostate cancer cells in vitro and in vivo.Synonyms: IRT1, Solute carrier family 39 member 1, ZIP-1, ZIP1, ZIRTL, Zinc-iron-regulated transporter-like, Zrt- and Irt-like protein 1