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TNF alpha Antikörper (AA 1-234)
TNF alpha
Reaktivität: Human, Ratte
WB, IHC (p), EIA
Wirt: Maus
Monoclonal
M1-C4
unconjugated
Produktdetails anti-TNF alpha Antikörper
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Target
Alle TNF alpha Antikörper anzeigen
TNF alpha
(Tumor Necrosis Factor alpha (TNF alpha))
Bindungsspezifität
Alle Epitope für TNF alpha Antikörper
AA 1-234
Reaktivität
Alle Reaktivitäten für TNF alpha Antikörper
Human, Ratte
Wirt
Alle Wirte für TNF alpha Antikörper
Maus
Klonalität
Alle Klonalitäten für TNF alpha Antikörper
Monoklonal
Konjugat
Alle Konjugate für TNF alpha Antikörper
Dieser TNF alpha Antikörper ist unkonjugiert
Applikation
Alle Applikationen für TNF alpha Antikörper
Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
Spezifität
This antibody reacts to TNF.
Aufreinigung
Affinity chromatography on Protein A
Immunogen
TNF antibody was raised against tNF (AAH28148, 1 a.a. ~ 234 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Klon
M1-C4
Isotyp
IgG1
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Anwendungsinformationen
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Applikationshinweise
Optimal working dilution should be determined by the investigator.
Beschränkungen
Nur für Forschungszwecke einsetzbar
Handhabung
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Konzentration
0,5 mg/mL
Buffer
PBS, pH 7.2
Handhabung
Avoid repeated freezing and thawing.
Lagerung
4 °C/-20 °C
Informationen zur Lagerung
Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Details zu TNF alpha
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Target
TNF alpha
(Tumor Necrosis Factor alpha (TNF alpha))
Andere Bezeichnung
Tumor Necrosis Factor (TNF-Alpha) (TNF alpha Produkte )
Hintergrund
Tumor Necrosis Factor (TNF) is a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. TNF is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. TNF is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. TNF has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine.Synonyms: Cachectin, TNF, TNF-a, TNFA, TNFSF2, Tumor necrosis factor ligand superfamily member 2
Gen-ID
7124
NCBI Accession
NP_000585
UniProt
P01375
Pathways
NF-kappaB Signalweg , Apoptose , Caspase Kaskade in der Apoptose , TLR Signalweg , Cellular Response to Molecule of Bacterial Origin , Regulation of Leukocyte Mediated Immunity , Positive Regulation of Immune Effector Process , Production of Molecular Mediator of Immune Response , Positive Regulation of Endopeptidase Activity , Hepatitis C , Protein targeting to Nucleus , Inflammasome
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