IL-21 Antikörper (AA 65-155)

Produktnummer ABIN748133

Produktdetails anti-IL-21 Antikörper

Target: IL-21 (IL21) (Interleukin 21 (IL21))

Bindungsspezifität: AA 65-155

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser IL-21 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Kreuzreaktivität: Human, Maus

Homologie: Rat,Dog,Cow,Pig

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human IL-21

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IF(IHC-P) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Referenzen für anti-IL-21 Antikörper (ABIN748133)

Ma, Sun, Zhai, Yu, Wang, Li, Ding: "Effect of follicular helper T cells on the pathogenesis of asthma." in: Experimental and therapeutic medicine, Vol. 14, Issue 2, pp. 967-972, (2017) (PubMed).

Gong, Zhu, Pang, Ai, Gong, La, Ding: "Increased levels of CCR7(lo)PD-1(hi) CXCR5+ CD4+ T cells, and associated factors Bcl-6, CXCR5, IL-21 and IL-6 contribute to repeated implantation failure." in: Experimental and therapeutic medicine, Vol. 14, Issue 6, pp. 5931-5941, (2017) (PubMed).

Guan, Wang, Meng, Shi, Jiang, Xiao, Shi, Xu, Zhang: "Increased IL-21/IL-21R expression and its proinflammatory effects in autoimmune thyroid disease." in: Cytokine, Vol. 72, Issue 2, pp. 160-5, (2015) (PubMed).

Details zu IL-21

Target: IL-21 (IL21) (Interleukin 21 (IL21))

Andere Bezeichnung: IL-21 (IL21 Produkte)

Hintergrund:

Synonyms: Za11, IL-21, CVID11, Interleukin-21, IL21

Background: Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells (By similarity). May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells. During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation.

Gen-ID: 59067

UniProt: Q9HBE4

Pathways: JAK-STAT Signalweg, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response