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WEE1 Antikörper (pSer642)

WEE1 Reaktivität: Human WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN746873
  • Target Alle WEE1 Antikörper anzeigen
    WEE1 (WEE1 Homolog (S. Pombe) (WEE1))
    Bindungsspezifität
    • 19
    • 15
    • 12
    • 11
    • 9
    • 8
    • 8
    • 7
    • 5
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pSer642
    Reaktivität
    • 96
    • 55
    • 43
    • 2
    Human
    Wirt
    • 106
    • 5
    • 2
    Kaninchen
    Klonalität
    • 111
    • 2
    Polyklonal
    Konjugat
    • 47
    • 9
    • 8
    • 7
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    Dieser WEE1 Antikörper ist unkonjugiert
    Applikation
    • 84
    • 51
    • 27
    • 27
    • 24
    • 16
    • 7
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Homologie
    Human,Mouse,Rat,Dog,Cow,Pig,Rabbit
    Aufreinigung
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic phosphopeptide derived from human Wee1 around the phosphorylation site of Ser642 [SV(p-S)LT]
    Isotyp
    IgG
  • Applikationshinweise
    WB 1:300-5000
    ELISA 1:500-1000
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Haltbarkeit
    12 months
  • Target
    WEE1 (WEE1 Homolog (S. Pombe) (WEE1))
    Andere Bezeichnung
    Wee1 (WEE1 Produkte)
    Synonyme
    WEE1A antikoerper, WEE1hu antikoerper, ATWEE1 antikoerper, F22D16.3 antikoerper, F22D16_3 antikoerper, WEE1 kinase homolog antikoerper, WEE1-KINASE antikoerper, WEE1 antikoerper, Xe-Wee1B antikoerper, XeWee1B antikoerper, wee1-b antikoerper, wee1a antikoerper, wee2-a antikoerper, xe-wee1a antikoerper, xwee1 antikoerper, wee1 antikoerper, wee1b antikoerper, wee1hu antikoerper, xwee2 antikoerper, GB19689 antikoerper, Wee1A antikoerper, fa20h03 antikoerper, wu:fa20h03 antikoerper, zgc:136514 antikoerper, WEE1 G2 checkpoint kinase antikoerper, Wee1 kinase antikoerper, WEE1-like kinase antikoerper, WEE1 G2 checkpoint kinase S homeolog antikoerper, wee1 homolog antikoerper, WEE1 homolog 2 antikoerper, wee1-like protein kinase antikoerper, WEE 1 homolog 1 (S. pombe) antikoerper, M phase inhibitor protein kinase Wee1 antikoerper, WEE1 antikoerper, Wee1 antikoerper, wee1.S antikoerper, wee1-a antikoerper, wee2 antikoerper, LOC551677 antikoerper, wee1 antikoerper
    Hintergrund

    Synonyms: WEE1A, WEE1hu, Wee1-like protein kinase, Wee1A kinase, WEE1

    Background: Acts as a negative regulator of entry into mitosis (G2 to M transition) by protecting the nucleus from cytoplasmically activated cyclin B1-complexed CDK1 before the onset of mitosis by mediating phosphorylation of CDK1 on 'Tyr-15'. Specifically phosphorylates and inactivates cyclin B1-complexed CDK1 reaching a maximum during G2 phase and a minimum as cells enter M phase. Phosphorylation of cyclin B1-CDK1 occurs exclusively on 'Tyr-15' and phosphorylation of monomeric CDK1 does not occur. Its activity increases during S and G2 phases and decreases at M phase when it is hyperphosphorylated. A correlated decrease in protein level occurs at M/G1 phase, probably due to its degradation.

    Gen-ID
    7465
    UniProt
    P30291
    Pathways
    Zellzyklus, Mitotic G1-G1/S Phases, M Phase
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