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TR4 Antikörper (pThr187)

NR2C2 Reaktivität: Human, Ratte, Maus WB, ELISA, IF (cc), IF (p), IHC (p), FACS, IHC (fro) Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN746333
  • Target Alle TR4 (NR2C2) Antikörper anzeigen
    TR4 (NR2C2) (Nuclear Receptor Subfamily 2, Group C, Member 2 (NR2C2))
    Bindungsspezifität
    • 30
    • 30
    • 15
    • 15
    • 14
    • 11
    • 9
    • 9
    • 8
    • 7
    • 5
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pThr187
    Reaktivität
    • 156
    • 113
    • 105
    • 8
    • 6
    • 6
    • 5
    • 5
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    Human, Ratte, Maus
    Wirt
    • 160
    • 10
    • 1
    • 1
    Kaninchen
    Klonalität
    • 156
    • 16
    Polyklonal
    Konjugat
    • 53
    • 12
    • 9
    • 9
    • 9
    • 9
    • 9
    • 9
    • 8
    • 8
    • 5
    • 5
    • 5
    • 5
    • 5
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser TR4 Antikörper ist unkonjugiert
    Applikation
    • 126
    • 65
    • 65
    • 45
    • 28
    • 26
    • 15
    • 15
    • 6
    • 3
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Kreuzreaktivität
    Human, Maus, Ratte
    Homologie
    Cow,Pig,Horse,Chicken,Rabbit
    Aufreinigung
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic phosphopeptide derived from human TAK1 around the phosphorylation site of Thr187
    Isotyp
    IgG
    Top Product
    Discover our top product NR2C2 Primärantikörper
  • Applikationshinweise
    WB 1:300-5000
    ELISA 1:500-1000
    FCM 1:20-100
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Haltbarkeit
    12 months
  • Dvashi, Goldberg, Adir, Shapira, Pollack: "TGF-?1 induced transdifferentiation of rpe cells is mediated by TAK1." in: PLoS ONE, Vol. 10, Issue 4, pp. e0122229, (2015) (PubMed).

  • Target
    TR4 (NR2C2) (Nuclear Receptor Subfamily 2, Group C, Member 2 (NR2C2))
    Andere Bezeichnung
    TAK1 (NR2C2 Produkte)
    Synonyme
    TAK1 antikoerper, TR2R1 antikoerper, TR4 antikoerper, hTAK1 antikoerper, Tr4 antikoerper, gb:dq017625 antikoerper, im:6911408 antikoerper, mKIAA4145 antikoerper, nuclear receptor subfamily 2 group C member 2 antikoerper, nuclear receptor subfamily 2, group C, member 2 antikoerper, NR2C2 antikoerper, Nr2c2 antikoerper, nr2c2 antikoerper
    Hintergrund

    Synonyms: TAK1, MEKK7, TGF1a, Mitogen-activated protein kinase kinase kinase 7, Transforming growth factor-beta-activated kinase 1, TGF-beta-activated kinase 1, MAP3K7

    Background: Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signal transduction of TRAF6, various cytokines including interleukin-1 (IL-1), transforming growth factor-beta (TGFB), TGFB-related factors like BMP2 and BMP4, toll-like receptors (TLR), tumor necrosis factor receptor CD40 and B-cell receptor (BCR). Ceramides are also able to activate MAP3K7/TAK1. Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases like MAP2K1/MEK1, MAP2K3/MKK3, MAP2K6/MKK6 and MAP2K7/MKK7. These MAP2Ks in turn activate p38 MAPKs, c-jun N-terminal kinases (JNKs) and I-kappa-B kinase complex (IKK). Both p38 MAPK and JNK pathways control the transcription factors activator protein-1 (AP-1), while nuclear factor-kappa B is activated by IKK. MAP3K7 activates also IKBKB and MAPK8/JNK1 in response to TRAF6 signaling and mediates BMP2-induced apoptosis. In osmotic stress signaling, plays a major role in the activation of MAPK8/JNK1, but not that of NF-kappa-B. Promotes TRIM5 capsid-specific restriction activity.

    Gen-ID
    6885
    UniProt
    O43318
    Pathways
    T-Zell Rezeptor Signalweg, Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Tube Formation, Toll-Like Receptors Cascades
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