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PFKFB3 Antikörper (pSer467)

PFKFB3 Reaktivität: Human, Maus, Ratte WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN744728
  • Target Alle PFKFB3 Antikörper anzeigen
    PFKFB3 (6-phosphofructo-2-Kinase/fructose-2,6-Biphosphatase 3 (PFKFB3))
    Bindungsspezifität
    • 15
    • 15
    • 15
    • 14
    • 9
    • 4
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    pSer467
    Reaktivität
    • 83
    • 71
    • 60
    • 4
    • 3
    • 3
    • 3
    • 1
    • 1
    Human, Maus, Ratte
    Wirt
    • 92
    • 5
    Kaninchen
    Klonalität
    • 87
    • 12
    Polyklonal
    Konjugat
    • 40
    • 6
    • 5
    • 5
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    Dieser PFKFB3 Antikörper ist unkonjugiert
    Applikation
    • 71
    • 39
    • 39
    • 30
    • 23
    • 15
    • 10
    • 8
    • 7
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Spezifität
    This phosphorylated site is homologous to that of Ser467 in Mouse and Ser496 in Rat.
    Kreuzreaktivität
    Human, Maus, Ratte
    Homologie
    Cow,Pig,Horse,Chicken,Rabbit
    Aufreinigung
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic phosphopeptide derived from human PFK2 around the phosphorylation site of Ser467
    Isotyp
    IgG
    Top Product
    Discover our top product PFKFB3 Primärantikörper
  • Applikationshinweise
    WB 1:300-5000
    ELISA 1:500-1000
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Haltbarkeit
    12 months
  • Fu, Shi, Westaway, Jhamandas: "Bioenergetic mechanisms in astrocytes may contribute to amyloid plaque deposition and toxicity." in: The Journal of biological chemistry, Vol. 290, Issue 20, pp. 12504-13, (2015) (PubMed).

  • Target
    PFKFB3 (6-phosphofructo-2-Kinase/fructose-2,6-Biphosphatase 3 (PFKFB3))
    Andere Bezeichnung
    PFK2 (PFKFB3 Produkte)
    Synonyme
    IPFK2 antikoerper, PFK2 antikoerper, E330010H22Rik antikoerper, iPFK-2 antikoerper, uPFK-2 antikoerper, PFKFB3 antikoerper, zgc:73257 antikoerper, wu:fc31e01 antikoerper, 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 antikoerper, 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 S homeolog antikoerper, PFKFB3 antikoerper, Pfkfb3 antikoerper, pfkfb3.S antikoerper, pfkfb3 antikoerper, PTRG_09894 antikoerper, Tsp_06710 antikoerper
    Hintergrund

    Synonyms: PFK2, IPFK2, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3, 6PF-2-K/Fru-2,6-P2ase 3, PFK/FBPase 3, 6PF-2-K/Fru-2,6-P2ase brain/placenta-type isozyme, Renal carcinoma antigen NY-REN-56, iPFK-2, PFKFB3

    Background: 6 Phosphofructo 2 Kinase plays a role in the synthesis and degradation of fructose 2,6-bisphosphate. Fructose-2,6-bisphosphate acts as an allosteric regulator of 6-phosphofructo-1-kinase (PFK1), which catalyses a key step in the glycoytic pathway. Glycolytic flux is key to tumour growth, and small molecule inhibition of 6 Phosphofructo 2 Kinase suppresses both glycolytic flux and tumour growth. Several lines of evidence suggest that 6 Phosphofructo 2 Kinase is also involved in obesity.

    Gen-ID
    5209
    UniProt
    Q16875
    Pathways
    AMPK Signaling, Regulation of Carbohydrate Metabolic Process
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