GRIN2B Antikörper (Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2B) (AA 1434-1484)

Details for Product anti-GRIN2B Antibody No. ABIN744368, Anbieter: Anmelden zum Anzeigen
Antigen
  • NMDAR2B
  • GluN2B
  • MRD6
  • NR2B
  • hNR3
  • nmdar2b
  • nr2b
  • AW490526
  • Nmdar2b
  • glutamate ionotropic receptor NMDA type subunit 2B
  • glutamate receptor, ionotropic, N-methyl D-aspartate 2B L homeolog
  • glutamate receptor, ionotropic, NMDA2B (epsilon 2)
  • GRIN2B
  • Grin2b
  • grin2b.L
Epitop
AA 1434-1484
90
66
53
38
32
29
19
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10
5
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2
1
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Reaktivität
Human, Maus, Ratte (Rattus)
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384
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21
15
9
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2
2
2
1
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Wirt
Kaninchen
335
115
16
Klonalität
Polyklonal
Konjugat
Dieser GRIN2B Antikörper ist unkonjugiert
15
15
13
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11
9
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1
Applikation
Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
326
162
114
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91
78
71
25
12
7
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3
1
1
Optionen
Hersteller
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Hersteller Produkt- Nr.
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Immunogen KLH conjugated synthetic peptide derived from mouse NMDAR2B
Isotyp IgG
Reinigung Purified by Protein A.
Plasmids, Primers & others Plasmide, Primers & weitere GRIN2B products on genomics-online (e.g. as negative or positive controls)
Antigen
Andere Bezeichnung Nmdar2b (GRIN2B Antibody Abstract)
Hintergrund

NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-133 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death (By similarity).

Subcellular location: Cytoplasm

Synonyms: MRD6, NR2B, hNR3, GluN2B, NMDAR2B, Glutamate receptor ionotropic, NMDA 2B, Glutamate [NMDA] receptor subunit epsilon-2, N-methyl D-aspartate receptor subtype 2B, N-methyl-D-aspartate receptor subunit 3, NR3, GRIN2B

Gen-ID 2904
UniProt Q13224
Pathways Response to Growth Hormone Stimulus, Synaptic Membrane, Feeding Behaviour, Regulation of long-term Neuronal Synaptic Plasticity
Applikations-hinweise IHC-P 1:100-500
IF(IHC-P) 1:50-200
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20°C
Haltbarkeit 12 months
Bilder des Herstellers
Immunohistochemistry (IHC) image for anti-Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2B (GRIN2B) (AA 1434-1484) antibody (ABIN744368) Formalin-fixed and paraffin embedded rat brain labeled with Rabbit Anti NMDAR2B Polyc...
Immunofluorescence (IF) image for anti-Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2B (GRIN2B) (AA 1434-1484) antibody (ABIN744368) Formalin-fixed and paraffin-embedded rat brain labeled with Anti-NMDAR2B Polyclonal A...
Produkt verwendet in: Li, Wang, Guo, Huang, Zhao, Zhu, Ma, Liang, Zhang, Huang, Wan: "Protective effect of Xingnaojia formulation on rats with brain and liver damage caused by chronic alcoholism." in: Experimental and therapeutic medicine, Vol. 10, Issue 5, pp. 1643-1652, 2015 (PubMed). Von den Autoren verwendete Methode: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (Probematerial (Species): Rat (Rattus)). Weitere Details: Sample: Brain

Zhao, Li, Wei, Savage, Zhou, Ma: "Ketamine administered to pregnant rats in the second trimester causes long-lasting behavioral disorders in offspring." in: Neurobiology of disease, Vol. 68, pp. 145-55, 2014 (PubMed). Von den Autoren verwendete Methode: Western Blotting (WB) (Probematerial (Species): Rat (Rattus)). Weitere Details: Sample: Brain

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