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NEDD4-2 Antikörper (pSer342) (Cy3)

NEDD4L Reaktivität: Human IF (p), IF (cc) Wirt: Kaninchen Polyclonal Cy3
Produktnummer ABIN744251
  • Target Alle NEDD4-2 (NEDD4L) Antikörper anzeigen
    NEDD4-2 (NEDD4L) (E3 ubiquitin-protein ligase NEDD4-like (NEDD4L))
    Bindungsspezifität
    • 14
    • 8
    • 7
    • 7
    • 6
    • 6
    • 6
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    pSer342
    Reaktivität
    • 67
    • 44
    • 16
    • 5
    • 4
    • 4
    • 4
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Wirt
    • 76
    • 4
    Kaninchen
    Klonalität
    • 69
    • 11
    Polyklonal
    Konjugat
    • 32
    • 7
    • 5
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Dieser NEDD4-2 Antikörper ist konjugiert mit Cy3
    Applikation
    • 38
    • 25
    • 12
    • 12
    • 8
    • 7
    • 5
    • 5
    • 3
    • 1
    • 1
    • 1
    Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc))
    Homologie
    Human,Mouse,Rat,Cow,Pig,Horse,Chicken,Rabbit
    Aufreinigung
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic phosphopeptide derived from human NEDD4L around the phosphorylation site of Ser342
    Isotyp
    IgG
    Top Product
    Discover our top product NEDD4L Primärantikörper
  • Applikationshinweise
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Haltbarkeit
    12 months
  • Target
    NEDD4-2 (NEDD4L) (E3 ubiquitin-protein ligase NEDD4-like (NEDD4L))
    Andere Bezeichnung
    NEDD4L (NEDD4L Produkte)
    Synonyme
    NEDD4-2 antikoerper, NEDD4.2 antikoerper, RSP5 antikoerper, hNEDD4-2 antikoerper, nedd4 antikoerper, nedd4-2 antikoerper, NEDD4 antikoerper, Nedd4-2 antikoerper, 1300012C07Rik antikoerper, Nedd4b antikoerper, neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase antikoerper, NEDD4L antikoerper, neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase S homeolog antikoerper, neural precursor cell expressed, developmentally down-regulated gene 4-like antikoerper, NEDD4L antikoerper, LOC776799 antikoerper, nedd4l.S antikoerper, Nedd4l antikoerper
    Hintergrund

    Synonyms: E3 ubiquitin protein ligase NEDD4 like protein, E3 ubiquitin-protein ligase NEDD4-like, E3 ubiquitin-protein ligase NEDD4-like protein, KIAA0439, NED4L_HUMAN, NEDD4 2, NEDD4 2c, NEDD4-2, NEDD4-2a, NEDD4.2, NEDD4b, NEDD4L, NEDD4La, NEDD4Lb, NEDD4Lc, NEDD4Ld, NEDD4Le, NEDD4Lf, NEDD4Lg, NEDD4Lh, NEDL3, Neural precursor cell expressed developmentally down regulated 4 like E3 ubiquitin protein ligase, Neural precursor cell expressed, developmentally down regulated 4 like, RSP5, Ubiquitin protein ligase Rsp5.

    Background: E3 ubiquitin-protein ligase accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. This protein inhibits TGF-beta signaling by triggering SMAD2 and TGFR1 ubiquitination and proteasome-dependent degradation. Furthermore, it promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, Nav1.2, Nav1.3, Nav1.5, Nav1.7, Nav1.8, Kv1.3, EAAT1 or CLC5, and promotes the ubiquitination and degradation of SGK.

    Gen-ID
    23327
    Pathways
    Negative Regulation of Transporter Activity
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