Apelin Antikörper (AA 65-77)

Produktnummer ABIN740085

Produktdetails anti-Apelin Antikörper

Target: Apelin (APLN)

Bindungsspezifität: AA 65-77

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Apelin Antikörper ist unkonjugiert

Applikation: ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Spezifität: The antibody's immunogen sequence is derived from the Apelin-13 peptide. Therefore the Antibody can detect each of the active peptides that can be produced via proteolytic processing of the Apelin precursor.

Kreuzreaktivität: Human, Maus, Ratte

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Apelin

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Referenzen für anti-Apelin Antikörper (ABIN740085)

Kasacka, Piotrowska, Filipek, Lebkowski: "Comparative evaluation of cannabinoid receptors, apelin and S100A6 protein in the heart of women of different age groups." in: BMC cardiovascular disorders, Vol. 18, Issue 1, pp. 190, (2019) (PubMed).

Details zu Apelin

Target: Apelin (APLN)

Andere Bezeichnung: Apelin (APLN Produkte)

Synonyme: APLN antikoerper, Xapelin antikoerper, xnpep2 antikoerper, preproapelin antikoerper, 6030430G11Rik antikoerper, Apel antikoerper, APEL antikoerper, XNPEP2 antikoerper, apelin antikoerper, apelin S homeolog antikoerper, apln antikoerper, APLN antikoerper, apln.S antikoerper, Apln antikoerper

Hintergrund:

Synonyms: AGTRL1 ligand, APEL, APEL_HUMAN, Apelin-13, Apelin13, Apelin 13, APJ endogenous ligand, Apln, XNPEP2

Background: Apelin is a neuropeptide expressed in the supraoptic and paraventricular nuclei and is an endogenous ligand for APJ, a G protein-coupled orphan receptor which is an alternative coreceptor with CD4 for HIV-1. Apelin and APJ are ubiquitously expressed in peripheral tissues, with highest levels reported for heart and lungs, as well several regions within the central nervous system. The actions of apelin remain largely unknown: Apelin inhibits HIV-1 entry in cells coexpressing CD4 and APJ, the oral intake of Apelin in colostrum and breast milk could have a role in the modulation of the immune responses in neonates, more recent studies have also indicated a role for Apelin in the central control of body fluid homeostasis, by influencing AVP release and drinking behavior. In the cardiovascular system several actions of Apelin have been described, including endothelium-dependent vasodilatation, vasoconstriction through direct action on smooth muscle and positive inotropism.

Gen-ID: 8862

UniProt: Q9ULZ1

Pathways: Positive Regulation of Peptide Hormone Secretion, Hormone Activity, Feeding Behaviour