Ephrin A1 Antikörper (AA 101-205)

Produktnummer ABIN734108

Produktdetails anti-Ephrin A1 Antikörper

Target: Ephrin A1 (EFNA1)

Bindungsspezifität: AA 101-205

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Ephrin A1 Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Kreuzreaktivität: Human

Homologie: Mouse,Rat

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Ephrin A1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Details zu Ephrin A1

Target: Ephrin A1 (EFNA1)

Andere Bezeichnung: Ephrin A1 (EFNA1 Produkte)

Synonyme: Xefrin-A1 antikoerper, b61 antikoerper, ecklg antikoerper, efl1 antikoerper, efna1 antikoerper, efna1a antikoerper, elfa-a antikoerper, epha1 antikoerper, eplg1 antikoerper, lerk1 antikoerper, tnfaip4 antikoerper, xelf-a' antikoerper, xelfa antikoerper, AI325262 antikoerper, B61 antikoerper, Efl1 antikoerper, Epl1 antikoerper, Eplg1 antikoerper, Lerk1 antikoerper, ECKLG antikoerper, EFL1 antikoerper, EPLG1 antikoerper, LERK-1 antikoerper, LERK1 antikoerper, TNFAIP4 antikoerper, efna1b antikoerper, MGC130661 antikoerper, ephrin-A1 S homeolog antikoerper, ephrin-A1 antikoerper, ephrin A1 antikoerper, ephrin-A1b antikoerper, ephrin-A1 L homeolog antikoerper, efna1.S antikoerper, efna1 antikoerper, EFNA1 antikoerper, efna1b antikoerper, Efna1 antikoerper, efna1.L antikoerper

Hintergrund:

Synonyms: Ephrin-A1, EFNA1, EPH-related receptor tyrosine kinase ligand 1, LERK-1, Immediate early response protein B61, Tumor necrosis factor alpha-induced protein 4, EPLG1, LERK1, TNFAIP4

Background: Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. Exerts anti-oncogenic effects in tumor cells through activation and down-regulation of EPHA2. Activates EPHA2 by inducing tyrosine phosphorylation which leads to its internalization and degradation. Acts as a negative regulator in the tumorigenesis of gliomas by down-regulating EPHA2 and FAK. Can evoke collapse of embryonic neuronal growth cone and regulates dendritic spine morphogenesis.

Gen-ID: 1942

UniProt: P20827

Pathways: RTK Signalweg