Glucocorticoid Receptor Antikörper (AA 231-320)

Produktnummer ABIN726875

Produktdetails anti-Glucocorticoid Receptor Antikörper

Target: Glucocorticoid Receptor (NR3C1) (Nuclear Receptor Subfamily 3, Group C, Member 1 (Glucocorticoid Receptor) (NR3C1))

Bindungsspezifität: AA 231-320

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Glucocorticoid Receptor Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Kreuzreaktivität: Human, Maus, Ratte

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Glucocorticoid receptor

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Referenzen für anti-Glucocorticoid Receptor Antikörper (ABIN726875)

Guo, Ma, Xia, Chen, Li, Deng, Sheng, Hong, Hu: "Androgen receptor reverts dexamethasone‑induced inhibition of prostate cancer cell proliferation and migration." in: Molecular medicine reports, Vol. 17, Issue 4, pp. 5887-5893, (2018) (PubMed).

Pang, Zhang, Zhu, Guo: "Expression of glucocorticoid receptor-α in the epidermis of patients with psoriasis vulgaris." in: Experimental and therapeutic medicine, Vol. 10, Issue 2, pp. 419-422, (2015) (PubMed).

Takigawa, Miyazaki, Kinoshita, Kawarabayashi, Nishiyama, Hatsuse, Ono, Saitoh, Seki, Yamamoto: "Glucocorticoid receptor-dependent immunomodulatory effect of ursodeoxycholic acid on liver lymphocytes in mice." in: American journal of physiology. Gastrointestinal and liver physiology, Vol. 305, Issue 6, pp. G427-38, (2013) (PubMed).

Details zu Glucocorticoid Receptor

Target: Glucocorticoid Receptor (NR3C1) (Nuclear Receptor Subfamily 3, Group C, Member 1 (Glucocorticoid Receptor) (NR3C1))

Andere Bezeichnung: Glucocorticoid receptor (NR3C1 Produkte)

Synonyme: GR antikoerper, gcr antikoerper, grl antikoerper, xGR antikoerper, gccr antikoerper, gr antikoerper, zgc:113038 antikoerper, NR3C1 antikoerper, GCL antikoerper, LOC100302444 antikoerper, Gcr antikoerper, Grl antikoerper, Grl-1 antikoerper, Grl1 antikoerper, GRL antikoerper, GCCR antikoerper, GCR antikoerper, NO antikoerper, GR-A antikoerper, nr3c1 antikoerper, nuclear receptor subfamily 3 group C member 1 antikoerper, nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) antikoerper, nuclear receptor subfamily 3, group C, member 1 antikoerper, glucocorticoid receptor antikoerper, NR3C1 antikoerper, nr3c1 antikoerper, LOC100302444 antikoerper, Nr3c1 antikoerper

Hintergrund:

Synonyms: GR, GCR, GRL, GCCR, GCRST, Glucocorticoid receptor, Nuclear receptor subfamily 3 group C member 1, NR3C1

Background: Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth. Involved in chromatin remodeling. May play a negative role in adipogenesis through the regulation of lipolytic and antilipogenic genes expression.

Gen-ID: 2908

UniProt: P04150

Pathways: Nuclear Receptor Transcription Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process, Regulation of Muscle Cell Differentiation, Regulation of Carbohydrate Metabolic Process