FOXP3 Antikörper (Elab Fluor®700)

Produktnummer ABIN7566960

Der Maus Monoklonal Anti-FOXP3-Antikörper wurde für FACS validiert. Er ist geeignet, FOXP3 in Proben von Maus zu detektieren.

Kurzübersicht für FOXP3 Antikörper (Elab Fluor®700) (ABIN7566960)

Target: FOXP3 (Forkhead Box P3 (FOXP3))

Reaktivität: Maus

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser FOXP3 Antikörper ist konjugiert mit Elab Fluor®700

Applikation: Flow Cytometry (FACS)

Klon: 3G3

Produktdetails anti-FOXP3 Antikörper (Elab Fluor®700)

Verwendungszweck: Elab Fluor®700 Anti-Mouse Foxp3 Antibody[3G3]

Isotyp: IgG1, kappa

Anwendungsinformationen

Applikationshinweise: Each lot of this antibody is quality control tested by flow cytometric analysis. Applications vary, the appropriate dilutions must be determined for individual use.

Kommentare:

Matching Isotype Control: E-AB-F09792M1

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Phosphate buffered solution, pH 7.2, containing 0.09 % stabilizer and 1 % protein protectant.

Lagerung: 4 °C

Informationen zur Lagerung: This product can be stored at 2-8°C for 12 months. Please protected from prolonged exposure to light and do not freeze.

Haltbarkeit: 12 months

Details zu FOXP3

Target: FOXP3 (Forkhead Box P3 (FOXP3))

Andere Bezeichnung: Foxp3

Hintergrund: Forkhead box protein P3,Foxp3,IPEX,JM2,Foxp3 is a 50-55 kD transcription factor, also known as Forkhead box protein P3, Scurfin, JM2, or IPEX. It is proposed to be a master regulatory gene and more specific marker of T regulatory cells than most cell surface markers (such as CD4 and CD25). Transduced expression of Foxp3 in CD4+/CD25- cells has been shown to induce GITR, CD103, and CTLA4 and impart a T regulatory cell phenotype. Foxp3 is mutated in X-linked autoimmunity-allergic dysregulation syndrome (XLAAD or IPEX) in humans and in 'scurfy' mice. Overexpression of Foxp3 has been shown to lead to a hypoactive immune state suggesting that this transcriptional factor is a central regulator of T cell activity. In human, unlike in mouse, two isoforms of Foxp3 have been reported: one (Foxp3) corresponding to the canonical full-length sequence, the other (Foxp3 δ2) lacking exon 2.

Gen-ID: 50943, 20371, 317382

UniProt: Q99JB6

Pathways: Chromatin Binding, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Activated T Cell Proliferation