SMAD7 Antikörper (AA 1-100)

Produktnummer ABIN7270356

Produktdetails anti-SMAD7 Antikörper

Target: SMAD7 (SMAD, Mothers Against DPP Homolog 7 (SMAD7))

Bindungsspezifität: AA 1-100

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SMAD7 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Verwendungszweck: Smad7 Rabbit pAb

Sequenz: MFRTKRSALV RRLWRSRAPG GEDEEEGAGG GGGGGELRGE GATDSRAHGA GGGGPGRAGC CLGKAVRGAK GHHHPHPPAA GAGAAGGAEA DLKALTHSVL

Kreuzreaktivität: Human, Maus, Ratte

Produktmerkmale: Polyclonal Antibodies

Aufreinigung: Affinity purification

Immunogen: A synthetic peptide corresponding to a sequence within amino acids 1-100 of human Smad7 (NP_005895.1).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu SMAD7

Target: SMAD7 (SMAD, Mothers Against DPP Homolog 7 (SMAD7))

Andere Bezeichnung: SMAD7 (SMAD7 Produkte)

Synonyme: CRCS3 antikoerper, MADH7 antikoerper, MADH8 antikoerper, Smad7a antikoerper, Madh7 antikoerper, Smad10 antikoerper, madh7 antikoerper, xsmad7 antikoerper, wu:fj60c10 antikoerper, SMAD family member 7 antikoerper, SMAD family member 7 L homeolog antikoerper, SMAD7 antikoerper, Smad7 antikoerper, smad7.L antikoerper, smad7 antikoerper

Hintergrund: The protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 (TGFBR1), leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3). Several transcript variants encoding different isoforms have been found for this gene.,SMAD7,CRCS3,MADH7,MADH8,Epigenetics & Nuclear Signaling,Signal Transduction,Cell Biology & Developmental Biology,TGF-b-Smad Signaling Pathway,SMADs,SMAD7

Molekulargewicht: 23kDa/46kDa

Gen-ID: 4092

UniProt: O15105

Pathways: Interferon-gamma Pathway, Cell-Cell Junction Organization