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SLFN11 Antikörper

SLFN11 Reaktivität: Human WB Wirt: Kaninchen Monoclonal unconjugated
Produktnummer ABIN7270159
  • Target Alle SLFN11 Produkte
    SLFN11 (Schlafen Family Member 11 (SLFN11))
    Reaktivität
    • 6
    • 1
    Human
    Wirt
    • 6
    Kaninchen
    Klonalität
    • 6
    Monoklonal
    Konjugat
    • 2
    • 2
    • 1
    • 1
    Dieser SLFN11 Antikörper ist unkonjugiert
    Applikation
    • 5
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB)
    Verwendungszweck
    SLFN11 Rabbit mAb
    Kreuzreaktivität
    Human
    Produktmerkmale
    Monoclonal Antibodies
    Aufreinigung
    Affinity purification
    Immunogen
    Recombinant protein of human SLFN11.
    Isotyp
    IgG
  • Applikationshinweise
    WB,1:500 - 1:2000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C. Avoid freeze / thaw cycles.
  • Target
    SLFN11 (Schlafen Family Member 11 (SLFN11))
    Andere Bezeichnung
    SLFN11 (SLFN11 Produkte)
    Synonyme
    SLFN8/9 antikoerper, schlafen family member 11 antikoerper, SLFN11 antikoerper, LOC100071612 antikoerper
    Hintergrund
    Inhibitor of DNA replication that promotes cell death in response to DNA damage. Acts as a guardian of the genome by killing cells with defective replication. Persistently blocks stressed replication forks by opening chromatin across replication initiation sites at stressed replication forks, possibly leading to unwind DNA ahead of the MCM helicase and block fork progression, ultimately leading to cell death. Acts independently of ATR. Also acts as an interferon (IFN-induced antiviral protein which acts as an inhibitor of retrovirus protein synthesis. Specifically abrogates the production of retroviruses such as human immunodeficiency virus 1 (HIV-1 by acting as a specific inhibitor of the synthesis of retroviruses encoded proteins in a codon-usage-dependent manner. Binds to tRNAs and exploits the unique viral codon bias towards A/T nucleotides. The exact inhibition mechanism is unclear: may either sequester tRNAs, prevent their maturation via post-transcriptional processing or may accelerate their deacylation. Does not inhibit reverse transcription, integration or production and nuclear export of viral RNA.,SLFN8/9,SLFN11
    Molekulargewicht
    102kDa
    Gen-ID
    91607
    UniProt
    Q7Z7L1
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