NSD1 Antikörper

Produktnummer ABIN7191723

Produktdetails anti-NSD1 Antikörper

Target: NSD1 (Nuclear Receptor Binding SET Domain Protein 1 (NSD1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NSD1 Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (IHC)

Kreuzreaktivität: Human, Maus

Aufreinigung: Antigen affinity purification

Immunogen: Synthetic peptide of Human NSD1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA:1:2000-1:5000, IHC:1:25-1:100,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: -20 °C, pH 7.4 PBS, 0.05 % Sodium azide, 40 % Glycerol

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu NSD1

Target: NSD1 (Nuclear Receptor Binding SET Domain Protein 1 (NSD1))

Andere Bezeichnung: NSD1 (NSD1 Produkte)

Synonyme: NSD1 antikoerper, sto antikoerper, kmt3b antikoerper, sotos antikoerper, ara267 antikoerper, ARA267 antikoerper, KMT3B antikoerper, SOTOS antikoerper, SOTOS1 antikoerper, STO antikoerper, AI528500 antikoerper, nuclear receptor binding SET domain protein 1 antikoerper, histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific antikoerper, nuclear receptor-binding SET-domain protein 1 antikoerper, NSD1 antikoerper, nsd1 antikoerper, Nsd1 antikoerper, LOC540197 antikoerper

Hintergrund:

Background: This gene encodes a protein containing a SET domain, 2 LXXLL motifs, 3 nuclear translocation signals (NLSs), 4 plant homeodomain (PHD) finger regions, and a proline-rich region. The encoded protein enhances androgen receptor (AR) transactivation, and this enhancement can be increased further in the presence of other androgen receptor associated coregulators. This protein may act as a nucleus-localized, basic transcriptional factor and also as a bifunctional transcriptional regulator. Mutations of this gene have been associated with Sotos syndrome and Weaver syndrome. One version of childhood acute myeloid leukemia is the result of a cryptic translocation with the breakpoints occurring within nuclear receptor-binding Su-var, enhancer of zeste, and trithorax domain protein 1 on chromosome 5 and nucleoporin, 98-kd on chromosome 11. Two transcript variants encoding distinct isoforms have been identified for this gene.

Aliases: nuclear receptor binding SET domain protein 1

UniProt: Q96L73