FGF23 Antikörper (AA 21-120)

Produktnummer ABIN714461

Produktdetails anti-FGF23 Antikörper

Target: FGF23 (Fibroblast Growth Factor 23 (FGF23))

Bindungsspezifität: AA 21-120

Reaktivität: Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FGF23 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc))

Kreuzreaktivität: Ratte

Homologie: Human,Mouse,Dog,Cow,Sheep,Pig,Horse,Rabbit,Guinea Pig

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human FGF23

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Referenzen für anti-FGF23 Antikörper (ABIN714461)

Schumacher, Alampour-Rajabi, Ponomariov, Curaj, Wu, Staudt, Rusu, Jankowski, Marx, Jankowski, Brandenburg, Liehn, Schuh: "Cardiac FGF23: new insights into the role and function of FGF23 after acute myocardial infarction." in: Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology, Vol. 40, pp. 47-54, (2019) (PubMed).

Andersen, Huntley, Sandberg, Heublein, Burnett: "Elevation of circulating but not myocardial FGF23 in human acute decompensated heart failure." in: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, Vol. 31, Issue 5, pp. 767-72, (2016) (PubMed).

Details zu FGF23

Target: FGF23 (Fibroblast Growth Factor 23 (FGF23))

Andere Bezeichnung: FGF23 (FGF23 Produkte)

Synonyme: FGF23 antikoerper, ADHR antikoerper, FGFN antikoerper, HPDR2 antikoerper, HYPF antikoerper, PHPTC antikoerper, fibroblast growth factor 23 antikoerper, fgf23 antikoerper, FGF23 antikoerper, Fgf23 antikoerper

Hintergrund:

Synonyms: ADHR, FGFN, HYPF, HPDR2, PHPTC, Fibroblast growth factor 23, FGF-23, Phosphatonin, Tumor-derived hypophosphatemia-inducing factor, FGF23, UNQ327/PRO9828

Background: Regulator of phosphate homeostasis. Inhibits renal tubular phosphate transport by reducing SLC34A1 levels. Upregulates EGR1 expression in the presence of KL (By similarity). Acts directly on the parathyroid to decrease PTH secretion (By similarity). Regulator of vitamin-D metabolism. Negatively regulates osteoblast differentiation and matrix mineralization.

Gen-ID: 8074

UniProt: Q9GZV9

Pathways: RTK Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Negative Regulation of Hormone Secretion