NPC2 Antikörper (AA 20-151)

Produktnummer ABIN7161731

Produktdetails anti-NPC2 Antikörper

Target: NPC2 (Niemann-Pick Disease, Type C2 (NPC2))

Bindungsspezifität: AA 20-151

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NPC2 Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human NPC intracellular cholesterol transporter 2 protein (20-151AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu NPC2

Target: NPC2 (Niemann-Pick Disease, Type C2 (NPC2))

Andere Bezeichnung: NPC2 (NPC2 Produkte)

Synonyme: 2700012J19Rik antikoerper, AA408070 antikoerper, AU045843 antikoerper, HE1 antikoerper, EDDM1 antikoerper, re1 antikoerper, CE1 antikoerper, EPI-1 antikoerper, cb292 antikoerper, sb:cb292 antikoerper, NPC intracellular cholesterol transporter 2 antikoerper, Niemann-Pick disease, type C2 antikoerper, Npc2 antikoerper, NPC2 antikoerper, npc2 antikoerper

Hintergrund:

Background: Intracellular cholesterol transporter which acts in concert with NPC1 and plays an important role in the egress of cholesterol from the endosomal/lysosomal compartment. Both NPC1 and NPC2 function as the cellular \\\'tag team duo\\\' (TTD) to catalyze the mobilization of cholesterol within the multivesicular environment of the late endosome (LE) to effect egress through the limiting bilayer of the LE. NPC2 binds unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes and transfers it to the cholesterol-binding pocket of the N-terminal domain of NPC1. Cholesterol binds to NPC1 with the hydroxyl group buried in the binding pocket and is exported from the limiting membrane of late endosomes/ lysosomes to the ER and plasma membrane by an unknown mechanism. The secreted form of NCP2 regulates biliary cholesterol secretion via stimulation of ABCG5/ABCG8-mediated cholesterol transport.

Aliases: EDDM1 antibody, Epididymal protein 1 antibody, Epididymal secretory protein antibody, Epididymal secretory protein E1 antibody, hE1 antibody, Human epididymis-specific protein 1 antibody, Niemann-Pick disease type C2 antibody, Niemann-Pick disease type C2 protein antibody, NPC intracellular cholesterol transporter 2 antibody, NPC2 antibody, NPC2_HUMAN antibody, Tissue specific secretory protein antibody

UniProt: P61916

Pathways: SARS-CoV-2 Protein Interaktom