Human Immunodeficiency Virus Type-2 Vpx (HIV-2 Vpx) (AA 1-113) Antikörper (FITC)

Produktnummer ABIN7156079

Dieser Kaninchen Polyklonal Antikörper erkennt spezifisch in . Er zeigt eine Reaktivität gegenüber Human Immunodeficiency Virus (HIV).

Kurzübersicht für Human Immunodeficiency Virus Type-2 Vpx (HIV-2 Vpx) (AA 1-113) Antikörper (FITC) (ABIN7156079)

Target: Human Immunodeficiency Virus Type-2 Vpx (HIV-2 Vpx)

Reaktivität: Human Immunodeficiency Virus (HIV)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: FITC

Applikation: Bitte anfragen

Produktdetails

Bindungsspezifität: AA 1-113

Virus Strain: isolate BEN

Verwendungszweck: vpx Antibody, FITC conjugated

Kreuzreaktivität: Human Immunodeficiency Virus (HIV)

Aufreinigung: Protein G purified

Reinheit: >95 %

Immunogen: Recombinant Human immunodeficiency virus type 2 subtype A Protein Vpx protein (1-113AA)

Isotyp: IgG

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Antigendetails

Target: Human Immunodeficiency Virus Type-2 Vpx (HIV-2 Vpx)

Andere Bezeichnung: HIV (isolate BEN) (HIV-2) vpx

Substanzklasse: Viral Protein

Hintergrund:

Background: Plays a role in nuclear translocation of the viral pre-integration complex (PIC), thus is required for the virus to infect non-dividing cells. Targets specific host proteins for degradation by the 26S proteasome. Acts by associating with the cellular CUL4A-DDB1 E3 ligase complex through direct interaction with host VPRPB/DCAF-1. This change in the E3 ligase substrate specificity results in the degradation of host SAMHD1. In turn, SAMHD1 depletion allows viral replication in host myeloid cells by preventing SAMHD1-mediated hydrolysis of intracellular dNTPs necessary for reverse transcription.

Aliases: vpxProtein Vpx antibody, Viral protein X antibody, X ORF protein antibody

UniProt: P18099