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HLA-DQB1 Antikörper (AA 128-175) (HRP)

HLA-DQB1 Reaktivität: Human ELISA Wirt: Kaninchen Polyclonal HRP
Produktnummer ABIN7155600
  • Target Alle HLA-DQB1 Antikörper anzeigen
    HLA-DQB1 (Major Histocompatibility Complex, Class II, DQ beta 1 (HLA-DQB1))
    Bindungsspezifität
    • 5
    • 3
    • 2
    • 1
    • 1
    • 1
    AA 128-175
    Reaktivität
    • 20
    • 3
    • 1
    • 1
    • 1
    • 1
    Human
    Wirt
    • 17
    • 3
    Kaninchen
    Klonalität
    • 19
    • 1
    Polyklonal
    Konjugat
    • 11
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser HLA-DQB1 Antikörper ist konjugiert mit HRP
    Applikation
    • 10
    • 6
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    ELISA
    Kreuzreaktivität
    Human
    Aufreinigung
    >95%, Protein G purified
    Immunogen
    Recombinant Human HLA class II histocompatibility antigen, DQ beta 1 chain protein (128-175AA)
    Isotyp
    IgG
    Top Product
    Discover our top product HLA-DQB1 Primärantikörper
  • Applikationshinweise
    Optimal working dilution should be determined by the investigator.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C,-80 °C
    Informationen zur Lagerung
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Target
    HLA-DQB1 (Major Histocompatibility Complex, Class II, DQ beta 1 (HLA-DQB1))
    Andere Bezeichnung
    HLA-DQB1 (HLA-DQB1 Produkte)
    Synonyme
    CELIAC1 antikoerper, HLA-DQB antikoerper, IDDM1 antikoerper, mhc-DRB antikoerper, DLA-DQB antikoerper, MAMU-DQB1 antikoerper, LOC100172120 antikoerper, DKFZp469C0237 antikoerper, major histocompatibility complex, class II, DQ beta 1 antikoerper, HLA-DQB1 antikoerper, PATR-DQB1 antikoerper, DLA-DQB1 antikoerper, MAMU-DQB1 antikoerper, LOC100172120 antikoerper
    Hintergrund

    Background: Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading.

    Aliases: CELIAC1 antibody, DQ beta 1 chain antibody, DQB1_HUMAN antibody, HLA class II histocompatibility antigen antibody, HLA class II histocompatibility antigen, DQ beta 1 chain antibody, HLA class II histocompatibility antigen, DQ beta 2 chain antibody, HLA DQB antibody, HLA DQB1 antibody, HLA-DQB1 antibody, HLA-DQB2 antibody, IDDM1 antibody, Lymphocyte antigen antibody, Major histocompatibility complex class II beta antibody, Major histocompatibility complex, class II, DQ beta 1 antibody, MHC class II antigen DQB1 antibody, MHC class II antigen HLA DQ beta 1 antibody, MHC class II DQ beta chain antibody, MHC class II HLA DQ beta glycoprotein antibody, MHC class2 antigen antibody, MHC DQ beta antibody, OTTHUMP00000029167 antibody, OTTHUMP00000178569 antibody, OTTHUMP00000178570 antibody, OTTHUMP00000178571 antibody

    UniProt
    P01920
    Pathways
    T-Zell Rezeptor Signalweg, Production of Molecular Mediator of Immune Response, Cancer Immune Checkpoints
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