POLR3A Antikörper (AA 392-632) (Biotin)

Produktnummer ABIN7150447

Produktdetails anti-POLR3A Antikörper (Biotin)

Target: POLR3A (Polymerase (RNA) III (DNA Directed) Polypeptide A, 155kDa (POLR3A))

Bindungsspezifität: AA 392-632

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser POLR3A Antikörper ist konjugiert mit Biotin

Applikation: ELISA

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human DNA-directed RNA polymerase III subunit RPC1 protein (392-632AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu POLR3A

Target: POLR3A (Polymerase (RNA) III (DNA Directed) Polypeptide A, 155kDa (POLR3A))

Andere Bezeichnung: POLR3A (POLR3A Produkte)

Synonyme: 9330175N20Rik antikoerper, BC053071 antikoerper, RPC1 antikoerper, RPC155 antikoerper, RGD1305574 antikoerper, ADDH antikoerper, HLD7 antikoerper, hRPC155 antikoerper, polymerase (RNA) III (DNA directed) polypeptide A antikoerper, RNA polymerase III subunit A antikoerper, Polr3a antikoerper, POLR3A antikoerper

Hintergrund:

Background: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Forms the polymerase active center together with the second largest subunit. A single-stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol III. A bridging helix emanates from RPC1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol III by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition (By similarity). Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway.

Aliases: BC053071 antibody, DNA directed RNA polymerase III largest subunit antibody, DNA directed RNA polymerase III subunit A antibody, DNA-directed RNA polymerase III largest subunit antibody, DNA-directed RNA polymerase III subunit A antibody, DNA-directed RNA polymerase III subunit RPC1 antibody, hRPC155 antibody, MGC62420 antibody, POLR 3A antibody, POLR3A antibody, Polymerase (RNA) III (DNA directed) polypeptide A 155 kDa antibody, Polymerase (RNA) III (DNA directed) polypeptide A antibody, RGD1305574 antibody, RNA polymerase III 155 kDa subunit antibody, RNA polymerase III subunit C1 antibody, RNA polymerase III subunit C160 antibody, RNA polymerase III subunit RPC155 D antibody, RPC1 antibody, RPC1_HUMAN antibody, RPC155 antibody

UniProt: O14802