ALOX12B Antikörper (AA 484-663) (Biotin)

Produktnummer ABIN7144525

Produktdetails anti-ALOX12B Antikörper (Biotin)

Target: ALOX12B (Arachidonate 12-Lipoxygenase, 12R Type (ALOX12B))

Bindungsspezifität: AA 484-663

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ALOX12B Antikörper ist konjugiert mit Biotin

Applikation: ELISA

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Arachidonate 12-lipoxygenase, 12R-type protein (484-663AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu ALOX12B

Target: ALOX12B (Arachidonate 12-Lipoxygenase, 12R Type (ALOX12B))

Andere Bezeichnung: ALOX12B (ALOX12B Produkte)

Synonyme: ALOX12B antikoerper, MGC107915 antikoerper, MGC85124 antikoerper, 12R-LOX antikoerper, ARCI2 antikoerper, Aloxe2 antikoerper, e-LOX2 antikoerper, arachidonate 12-lipoxygenase, 12R type antikoerper, arachidonate 12-lipoxygenase, 12R type S homeolog antikoerper, ALOX12B antikoerper, alox12b antikoerper, alox12b.S antikoerper, Alox12b antikoerper

Hintergrund:

Background: Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Mainly converts arachidonic acid to (12R)-hydroperoxyeicosatetraenoic acid/(12R)-HPETE and minor stereoisomers. In the skin, acts upstream of ALOXE3 on the lineolate moiety of esterified omega-hydroxyacyl-sphingosine (EOS) ceramides to produce an epoxy-ketone derivative, a crucial step in the conjugation of omega-hydroxyceramide to membrane proteins. Therefore plays a crucial role in the synthesis of corneocytes lipid envelope and the establishment of the skin barrier to water loss. May also play a role in the regulation of the expression of airway mucins.

Aliases: ALOX12B antibody, Arachidonate 12-lipoxygenase antibody, 12R-type antibody, 12R-LOX antibody, 12R-lipoxygenase antibody, EC 1.13.11.- antibody, Epidermis-type lipoxygenase 12 antibody

UniProt: O75342

Pathways: Cell-Cell Junction Organization