PRKAG1 Antikörper (AA 1-331)

Produktnummer ABIN7142682

Produktdetails anti-PRKAG1 Antikörper

Target: PRKAG1 (Protein Kinase, AMP-Activated, gamma 1 Non-Catalytic Subunit (PRKAG1))

Bindungsspezifität: AA 1-331

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PRKAG1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Kreuzreaktivität: Human, Ratte

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human 5\\\'-AMP-activated protein kinase subunit gamma-1 protein (1-331AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu PRKAG1

Target: PRKAG1 (Protein Kinase, AMP-Activated, gamma 1 Non-Catalytic Subunit (PRKAG1))

Andere Bezeichnung: PRKAG1 (PRKAG1 Produkte)

Synonyme: MGC68503 antikoerper, zgc:63896 antikoerper, wu:fa94d09 antikoerper, wu:fd12h04 antikoerper, AMPKG antikoerper, Prkaac antikoerper, Prkga1 antikoerper, AA571379 antikoerper, BB036179 antikoerper, protein kinase, AMP-activated, gamma 1 non-catalytic subunit S homeolog antikoerper, protein kinase, AMP-activated, gamma 1 non-catalytic subunit antikoerper, protein kinase AMP-activated non-catalytic subunit gamma 1 antikoerper, prkag1.S antikoerper, prkag1 antikoerper, PRKAG1 antikoerper, Prkag1 antikoerper

Hintergrund:

Background: AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton, probably by indirectly activating myosin. Gamma non-catalytic subunit mediates binding to AMP, ADP and ATP, leading to activate or inhibit AMPK: AMP-binding results in allosteric activation of alpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits. ADP also stimulates phosphorylation, without stimulating already phosphorylated catalytic subunit. ATP promotes dephosphorylation of catalytic subunit, rendering the AMPK enzyme inactive.

Aliases: 5' AMP activated protein kinase gamma 1 subunit antibody, 5' AMP activated protein kinase subunit gamma 1 antibody, 5''-AMP-activated protein kinase subunit gamma-1 antibody, AAKG1_HUMAN antibody, AMP activated protein kinase noncatalytic gamma 1 subunit antibody, AMPK gamma 1 chain antibody, AMPK gamma1 antibody, AMPK subunit gamma-1 antibody, AMPKg antibody, MGC8666 antibody, PRKAG 1 antibody, PRKAG1 antibody, Protein kinase AMP activated gamma 1 non catalytic subunit antibody, protein kinase, AMP-activated, noncatalytic gamma-1 antibody

UniProt: P54619

Pathways: AMPK Signaling, Regulation of Carbohydrate Metabolic Process, Warburg Effekt