ROS1 Antikörper (AA 1-320) (HRP)

Produktnummer ABIN7140568

Produktdetails anti-ROS1 Antikörper (HRP)

Target: ROS1 (C-Ros Oncogene 1 , Receptor tyrosine Kinase (ROS1))

Bindungsspezifität: AA 1-320

Reaktivität: Arabidopsis thaliana

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ROS1 Antikörper ist konjugiert mit HRP

Applikation: ELISA

Kreuzreaktivität: Arabidopsis thaliana

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Arabidopsis thaliana Protein ROS1 protein (1-320AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu ROS1

Target: ROS1 (C-Ros Oncogene 1 , Receptor tyrosine Kinase (ROS1))

Andere Bezeichnung: ROS1 (ROS1 Produkte)

Synonyme: MCF3 antikoerper, ROS antikoerper, c-ros-1 antikoerper, ROS1C antikoerper, Ros-1 antikoerper, c-ros antikoerper, ROS proto-oncogene 1, receptor tyrosine kinase antikoerper, ROS proto-oncogene 1 , receptor tyrosine kinase antikoerper, Ros1 proto-oncogene antikoerper, ROS1 antikoerper, Ros1 antikoerper

Hintergrund:

Background: Bifunctional DNA glycosylase/lyase, which excises 5-methylcytosine (5-meC) and 5-hydroxymethylcytosine (5-hmeC), leaving an apyrimidinic (AP) site that is subsequently incised by the lyase activity (PubMed:25240767). Generates 3\'-phosphor-alpha,beta-unsaturated aldehyde (3\'-PUA) as a primary 5-meC excision intermediate (PubMed:25228464). Prevents DNA hypermethylation, specifically in the promoter of otherwise silenced loci. May be involved in DNA repair through its nicking activity on methylated DNA. Binds with similar affinity to both methylated and non-methylated DNA. Highly distributive behavior on DNA substrates containing multiple 5-meC residues. Involved with Pol IV in the remodeling of the 5S rDNA chromatin via DNA methylation modifications during the first days of development post-germination. Participates in UV-B induced- and oxidative DNA damage repair (PubMed:24155752).

Aliases: ROS1 antibody, DML1 antibody, At2g36490 antibody, F1O11.12 antibody, DNA glycosylase/AP lyase ROS1 antibody, EC 4.2.99.18 antibody, DEMETER-like protein 1 antibody, Protein REPRESSOR OF SILENCING 1 antibody, Protein ROS1 antibody

UniProt: Q9SJQ6

Pathways: RTK Signalweg