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Rekombinanter GSK3 beta Antikörper (pSer9)

GSK3b Reaktivität: Human WB, IHC, ELISA, IF Wirt: Kaninchen Monoclonal 3A6 unconjugated Recombinant Antibody
Produktnummer ABIN7321432
  • Target Alle GSK3 beta (GSK3b) Antikörper anzeigen
    GSK3 beta (GSK3b) (Glycogen Synthase Kinase 3 beta (GSK3b))
    Antikörpertyp
    Recombinant Antibody
    Bindungsspezifität
    • 6
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    pSer9
    Reaktivität
    • 21
    • 13
    • 9
    • 4
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    Human
    Wirt
    • 22
    • 2
    Kaninchen
    Klonalität
    • 21
    • 3
    Monoklonal
    Konjugat
    • 21
    • 1
    • 1
    • 1
    Dieser GSK3 beta Antikörper ist unkonjugiert
    Applikation
    • 21
    • 9
    • 9
    • 7
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)
    Kreuzreaktivität
    Human
    Aufreinigung
    Affinity-chromatography
    Immunogen
    A synthesized peptide derived from human Phospho-GSK3B (Ser9)
    Klon
    3A6
    Isotyp
    IgG
  • Applikationshinweise
    Recommended dilution: WB:1:500-1:5000, IHC:1:50-1:200, IF:1:20-1:200,
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C,-80 °C
    Informationen zur Lagerung
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Target
    GSK3 beta (GSK3b) (Glycogen Synthase Kinase 3 beta (GSK3b))
    Andere Bezeichnung
    GSK3B (GSK3b Produkte)
    Synonyme
    GSK3 antikoerper, GSK-3 antikoerper, C86142 antikoerper, GSK-3beta antikoerper, 7330414F15Rik antikoerper, 8430431H08Rik antikoerper, GSK3beta antikoerper, fk80d11 antikoerper, GSK-3[b] antikoerper, wu:fb68h05 antikoerper, wu:fk80d11 antikoerper, gsk-3 antikoerper, gsk3 antikoerper, gsk3-beta antikoerper, gsk3beta antikoerper, xgsk-3 antikoerper, glycogen synthase kinase 3 beta antikoerper, glycogen synthase kinase 3 beta L homeolog antikoerper, GSK3B antikoerper, Gsk3b antikoerper, gsk3b antikoerper, gsk3b.L antikoerper
    Hintergrund

    Background: Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), EIF2B, CTNNB1/beta-catenin, APC, AXIN1, DPYSL2/CRMP2, JUN, NFATC1/NFATC, MAPT/TAU and MACF1. Requires primed phosphorylation of the majority of its substrates. In skeletal muscle, contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis. May also mediate the development of insulin resistance by regulating activation of transcription factors. Regulates protein synthesis by controlling the activity of initiation factor 2B (EIF2BE/EIF2B5) in the same manner as glycogen synthase. In Wnt signaling, GSK3B forms a multimeric complex with APC, AXIN1 and CTNNB1/beta-catenin and phosphorylates the N-terminus of CTNNB1 leading to its degradation mediated by ubiquitin/proteasomes. Phosphorylates JUN at sites proximal to its DNA-binding domain, thereby reducing its affinity for DNA. Phosphorylates NFATC1/NFATC on conserved serine residues promoting NFATC1/NFATC nuclear export, shutting off NFATC1/NFATC gene regulation, and thereby opposing the action of calcineurin. Phosphorylates MAPT/TAU on 'Thr-548', decreasing significantly MAPT/TAU ability to bind and stabilize microtubules. MAPT/TAU is the principal component of neurofibrillary tangles in Alzheimer disease. Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. Phosphorylates MACF1, inhibiting its binding to microtubules which is critical for its role in bulge stem cell migration and skin wound repair. Probably regulates NF-kappa-B (NFKB1) at the transcriptional level and is required for the NF-kappa-B-mediated anti-apoptotic response to TNF-alpha (TNF/TNFA). Negatively regulates replication in pancreatic beta-cells, resulting in apoptosis, loss of beta-cells and diabetes. Through phosphorylation of the anti-apoptotic protein MCL1, may control cell apoptosis in response to growth factors deprivation. Phosphorylates MUC1 in breast cancer cells, decreasing the interaction of MUC1 with CTNNB1/beta-catenin. Is necessary for the establishment of neuronal polarity and axon outgrowth. Phosphorylates MARK2, leading to inhibit its activity. Phosphorylates SIK1 at 'Thr-182', leading to sustain its activity. Phosphorylates ZC3HAV1 which enhances its antiviral activity. Phosphorylates SNAI1, leading to its BTRC-triggered ubiquitination and proteasomal degradation. Phosphorylates SFPQ at 'Thr-687' upon T-cell activation. Phosphorylates NR1D1 st 'Ser-55' and 'Ser-59' and stabilizes it by protecting it from proteasomal degradation. Regulates the circadian clock via phosphorylation of the major clock components including ARNTL/BMAL1, CLOCK and PER2. Phosphorylates CLOCK AT 'Ser-427' and targets it for proteasomal degradation. Phosphorylates ARNTL/BMAL1 at 'Ser-17' and 'Ser-21' and primes it for ubiquitination and proteasomal degradation. Phosphorylates OGT at 'Ser-3' or 'Ser-4' which positively regulates its activity. Phosphorylates MYCN in neuroblastoma cells which may promote its degradation (PubMed:24391509).

    Aliases: Glycogen synthase kinase-3 beta, GSK-3 beta, Serine/threonine-protein kinase GSK3B, GSK3B

    UniProt
    P49841
    Pathways
    WNT Signalweg, Hedgehog Signalweg, Fc-epsilon Rezeptor Signalübertragung, Cellular Glucan Metabolic Process, ER-Nucleus Signaling, Regulation of Carbohydrate Metabolic Process, Hepatitis C, Autophagie, BCR Signaling, Warburg Effekt
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