USP44 Antikörper

Produktnummer ABIN7120522

Produktdetails anti-USP44 Antikörper

Target: USP44 (Ubiquitin Specific Peptidase 44 (USP44))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser USP44 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Aufreinigung: Immunogen affinity purified

Reinheit: ≥95 % as determined by SDS-PAGE

Immunogen: ubiquitin specific peptidase 44

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:500-1:5000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Haltbarkeit: 12 months

Details zu USP44

Target: USP44 (Ubiquitin Specific Peptidase 44 (USP44))

Andere Bezeichnung: USP44 (USP44 Produkte)

Synonyme: usp44 antikoerper, USP49 antikoerper, E430004F17Rik antikoerper, zgc:55661 antikoerper, ubiquitin specific peptidase 44 antikoerper, ubiquitin specific peptidase 44 L homeolog antikoerper, ubiquitin specific peptidase 44 S homeolog antikoerper, USP44 antikoerper, usp44.L antikoerper, usp44.S antikoerper, usp44 antikoerper, Usp44 antikoerper

Hintergrund: Synonyms:Deubiquitinating enzyme 44, DKFZp434D0127, FLJ14528, Ubiquitin thiolesterase 44, USP44 Background:Deubiquitinase that plays a key regulatory role in the spindle assembly checkpoint or mitotic checkpoint by preventing premature anaphase onset. Acts by specifically mediating deubiquitination of CDC20, a negative regulator of the anaphase promoting complex/cyclosome(APC/C). Deubiquitination of CDC20 leads to stabilize the MAD2L1-CDC20-APC/C ternary complex(also named mitotic checkpoint complex), thereby preventing premature activation of the APC/C. Promotes association of MAD2L1 with CDC20 and reinforces the spindle assembly checkpoint. Acts as a negative regulator of histone H2B(H2BK120ub1) ubiquitination.

Molekulargewicht: 81 kDa

Gen-ID: 84101

UniProt: Q9H0E7

Pathways: M Phase