TGFBRAP1 Antikörper

Produktnummer ABIN7120109

Produktdetails anti-TGFBRAP1 Antikörper

Target: TGFBRAP1 (Transforming Growth Factor, beta Receptor Associated Protein 1 (TGFBRAP1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TGFBRAP1 Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (IHC), Western Blotting (WB), Immunofluorescence (IF)

Aufreinigung: Immunogen affinity purified

Reinheit: ≥95 % as determined by SDS-PAGE

Immunogen: transforming growth factor, beta receptor associated protein 1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:500-1:2000, IHC: 1:20-1:200, IF: 1:20-1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Haltbarkeit: 12 months

Details zu TGFBRAP1

Target: TGFBRAP1 (Transforming Growth Factor, beta Receptor Associated Protein 1 (TGFBRAP1))

Andere Bezeichnung: TGFBRAP1 (TGFBRAP1 Produkte)

Synonyme: TRAP-1 antikoerper, TRAP1 antikoerper, 3110018K12Rik antikoerper, AU024090 antikoerper, AU042859 antikoerper, AW742551 antikoerper, Trap1 antikoerper, zgc:162302 antikoerper, transforming growth factor beta receptor associated protein 1 antikoerper, transforming growth factor, beta receptor associated protein 1 antikoerper, TGFBRAP1 antikoerper, tgfbrap1 antikoerper, Tgfbrap1 antikoerper

Hintergrund: Synonyms: Background:Plays a role in the TGF-beta/activin signaling pathway. It associates with inactive heteromeric TGF-beta and activin receptor complexes, mainly through the type II receptor, and is released upon activation of signaling. May recruit SMAD4 to the vicinity of the receptor complex and facilitate its interaction with receptor-regulated Smads, such as SMAD2. Plays a role in vesicle-mediated protein trafficking of the endocytic membrane transport pathway. Believed to act as a component of the putative CORVET endosomal tethering complexes which is proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations(PubMed:25266290). Functions predominantly in APPL1-containing endosomes and in degradative but not recycling trafficking of endocytosed cargo(PubMed:25266290).

Molekulargewicht: 80 kDa

Gen-ID: 9392

UniProt: Q8WUH2