MMP2 Antikörper (Matrix Metalloproteinase 2) (AA 409-434)

Details for Product anti-MMP2 Antibody No. ABIN707426, Anbieter: Anmelden zum Anzeigen
Antigen
  • 2-MMP
  • CG1794
  • DM2-MMP
  • Dm2-MMP
  • Dmel\\CG1794
  • MMP2
  • anon-WO0118547.84
  • dm-2MMP
  • dmmp2
  • l(2)02353
  • mmp2
  • wu:fa99h12
  • wu:fk89d01
  • fgmmp-2
  • Mmp-2
  • LOC100135793
  • Clg4a
  • GelA
  • MMP-2
  • CLG4
  • CLG4A
  • MMP-II
  • MONA
  • TBE-1
  • matrix metallopeptidase 2
  • Matrix metalloproteinase 2
  • matrix metalloproteinase 2
  • matrix metalloproteinase-2
  • MMP2
  • Mmp2
  • mmp2
  • LOC657982
  • LOC100135793
Epitop
AA 409-434
38
20
17
17
16
15
14
12
10
10
9
8
8
7
7
6
6
3
3
3
3
3
3
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
Reaktivität
Human, Maus, Ratte (Rattus)
434
188
178
32
18
15
14
11
7
6
6
5
5
2
2
2
2
2
1
1
1
Wirt
Kaninchen
248
214
3
2
1
1
Klonalität
Polyklonal
Konjugat
Dieser MMP2 Antikörper ist unkonjugiert
22
19
16
9
9
8
7
6
6
5
5
5
4
4
4
4
4
4
4
4
4
3
3
3
3
3
3
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
Applikation
Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
361
171
130
124
94
78
77
69
60
38
18
6
5
2
1
1
1
Optionen
Hersteller
Anmelden zum Anzeigen
Hersteller Produkt- Nr.
Anmelden zum Anzeigen
Immunogen KLH conjugated synthetic peptide derived from human MMP-2
Isotyp IgG
Reinigung Purified by Protein A.
Plasmids, Primers & others Plasmide, Primers & weitere MMP2 products on genomics-online (e.g. as negative or positive controls)
Andere Bezeichnung Mmp-2 (MMP2 Antibody Abstract)
Hintergrund

Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta-type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly-|-Leu bond. Appears to have a role in myocardial cell death pathways. Contributes to myocardial oxidative stress by regulating the activity of GSK3beta. Cleaves GSK3beta in vitro. Involved in the formation of the fibrovascular tissues in association with MMP14. PEX, the C-terminal non-catalytic fragment of MMP2, posseses anti-angiogenic and anti-tumor properties and inhibits cell migration and cell adhesion to FGF2 and vitronectin. Ligand for integrinv/beta3 on the surface of blood vessels. Isoform 2: Mediates the proteolysis of CHUK/IKKA and initiates a primary innate immune response by inducing mitochondrial-nuclear stress signaling with activation of the pro-inflammatory NF-kappaB, NFAT and IRF transcriptional pathways.

Subcellular location: Cytoplasm, Nucleus, Secreted, Mitochondrion, Membrane bound

Synonyms: CLG4, MONA, CLG4A, MMP-2, TBE-1, MMP-II, 72 kDa type IV collagenase, 72 kDa gelatinase, Gelatinase A, Matrix metalloproteinase-2, MMP2

Gen-ID 4313
UniProt P08253
Pathways Activation of Innate immune Response
Applikations-hinweise WB 1:100-1000
IHC-P 1:100-500
IF(IHC-P) 1:50-200
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20°C
Haltbarkeit 12 months
Bilder des Herstellers
Western Blotting (WB) image for anti-Matrix Metalloproteinase 2 (MMP2) (AA 409-434) antibody (ABIN707426) Rabbit heart lysates probed with Anti-MMP-2 Polyclonal Antibody, Unconjugated (ABIN70...
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-Matrix Metalloproteinase 2 (MMP2) (AA 409-434) antibody (ABIN707426) Formalin-fixed and paraffin embedded human laryngeal carcinoma labeled with Anti-MMP-...
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-Matrix Metalloproteinase 2 (MMP2) (AA 409-434) antibody (ABIN707426) Formalin-fixed and paraffin embedded human lung carcinoma labeled with Anti-MMP-2 Pol...
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-Matrix Metalloproteinase 2 (MMP2) (AA 409-434) antibody (ABIN707426) Paraformaldehyde-fixed, paraffin embedded rat bladder tissue, Antigen retrieval by bo...
Produkt verwendet in: Wang, Nikhil, Viccaro, Chang, White, Shah: "Phosphorylation-dependent regulation of ALDH1A1 by Aurora kinase A: insights on their synergistic relationship in pancreatic cancer." in: BMC biology, Vol. 15, Issue 1, pp. 10, 2017 (PubMed). Von den Autoren verwendete Methode: Western Blotting (WB), Western Blotting (WB) (Probematerial (Species): Human).

Liu, Chi, Lu, Zhang, Yamakawa: "Reversion-inducing-cysteine-rich Protein with Kazal Motif Is Involved in Intimal Hyperplasia in Carotid Arteries: A New Insight in the Prevention of Restenosis after Vascular Angioplasty." in: Annals of vascular surgery, Vol. 29, Issue 6, pp. 1293-9, 2015 (PubMed). Von den Autoren verwendete Methode: Western Blotting (WB) (Probematerial (Species): Human).

Cavdar, Ozbal, Celik, Ergur, Guneli, Ural, Camsari, Guner: "The effects of alpha-lipoic acid on MMP-2 and MMP-9 activities in a rat renal ischemia and re-perfusion model." in: Biotechnic & histochemistry : official publication of the Biological Stain Commission, Vol. 89, Issue 4, pp. 304-14, 2014 (PubMed). Von den Autoren verwendete Methode: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (Probematerial (Species): Rat (Rattus)). Weitere Details: Sample: kidney

Fan, Han, Zhu, Zhang, Zhu: "Ultrasensitive photoelectrochemical immunoassay for matrix metalloproteinase-2 detection based on CdS:Mn/CdTe cosensitized TiO2 nanotubes and signal amplification of SiO2@Ab2 conjugates." in: Analytical chemistry, Vol. 86, Issue 24, pp. 12398-405, 2014 (PubMed).

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