NDFIP1 Antikörper

Produktnummer ABIN7116768

Produktdetails anti-NDFIP1 Antikörper

Target: NDFIP1 (Nedd4 Family Interacting Protein 1 (NDFIP1))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NDFIP1 Antikörper ist unkonjugiert

Applikation: ELISA, Western Blotting (WB), Immunofluorescence (IF), Immunoprecipitation (IP)

Aufreinigung: Immunogen affinity purified

Reinheit: ≥95 % as determined by SDS-PAGE

Immunogen: Nedd4 family interacting protein 1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:500-1:2000, IP: 1:200-1:1000, IF: 1:20-1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Haltbarkeit: 12 months

Details zu NDFIP1

Target: NDFIP1 (Nedd4 Family Interacting Protein 1 (NDFIP1))

Andere Bezeichnung: NDFIP1 (NDFIP1 Produkte)

Synonyme: zgc:55546 antikoerper, wu:fc17e11 antikoerper, n4wbp5 antikoerper, MGC108163 antikoerper, ndfip1 antikoerper, NDFIP1 antikoerper, N4WBP5 antikoerper, 0610010M22Rik antikoerper, N4wbp5 antikoerper, Nedd4 family interacting protein 1 antikoerper, Nedd4 WW domain-binding protein 5 antikoerper, ndfip1 antikoerper, NDFIP1 antikoerper, n4wbp5 antikoerper, Ndfip1 antikoerper

Hintergrund: Synonyms:N4WBP5 Background:Activates HECT domain-containing E3 ubiquitin-protein ligases, including NEDD4 and ITCH, and consequently modulates the stability of their targets. As a result, controls many cellular processes. Prevents chronic T-helper cells-mediated inflammation by activating ITCH and thus controlling JUNB degradation(By similarity). In cortical neurons, mediates the ubiquitination of SLC11A2/DMT1 by NEDD4L, leading to down-regulation of the divalent metal transporter and protection of the cells from cobalt and iron toxicity(PubMed:19706893). Modulates EGFR signaling through multiple pathways. In particular, may regulate the ratio of AKT1-to-MAPK8 signaling in response to EGF, acting on AKT1 probably through PTEN destabilization and on MAPK8 through ITCH-dependent MAP2K4 inactivation. As a result, may control cell growth rate(PubMed:20534535). Enhances the ubiquitination of BRAT1 mediated by E3 ubiquitin-protein ligases: NEDD4, NEDD4L and ITCH, and is required for the nuclear localization of ubiquitinated BRAT1(PubMed:25631046).

Molekulargewicht: 30 kDa

Gen-ID: 80762

UniProt: Q9BT67

Pathways: Transition Metal Ion Homeostasis, Regulation of Leukocyte Mediated Immunity, Production of Molecular Mediator of Immune Response, Negative Regulation of Transporter Activity