GNAI1 Antikörper

Produktnummer ABIN7114816

Produktdetails anti-GNAI1 Antikörper

Target: GNAI1 (Guanine Nucleotide Binding Protein (G Protein), alpha Inhibiting Activity Polypeptide 1 (GNAI1))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GNAI1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FACS)

Aufreinigung: Immunogen affinity purified

Reinheit: ≥95 % as determined by SDS-PAGE

Immunogen: guanine nucleotide binding protein(G protein), alpha inhibiting activity polypeptide 1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:500-1:2000, IHC: 1:20-1:200, IF: 1:20-1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Haltbarkeit: 12 months

Details zu GNAI1

Target: GNAI1 (Guanine Nucleotide Binding Protein (G Protein), alpha Inhibiting Activity Polypeptide 1 (GNAI1))

Andere Bezeichnung: GNAI1 (GNAI1 Produkte)

Synonyme: AU046200 antikoerper, Gialpha1 antikoerper, Gnai-1 antikoerper, gnai1 antikoerper, Gi antikoerper, BPGTPB antikoerper, zgc:63957 antikoerper, guanine nucleotide binding protein (G protein), alpha inhibiting 1 antikoerper, G protein subunit alpha i1 antikoerper, guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 S homeolog antikoerper, guanine nucleotide-binding protein G(i) subunit alpha-1 antikoerper, guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 antikoerper, Gnai1 antikoerper, gnai1.S antikoerper, GNAI1 antikoerper, LOC397505 antikoerper, gnai1 antikoerper

Hintergrund: Synonyms: Background:Guanine nucleotide-binding proteins(G proteins) function as transducers downstream of G protein-coupled receptors(GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins(PubMed:8774883, PubMed:18434541). Signaling is mediated via effector proteins, such as adenylate cyclase. Inhibits adenylate cyclase activity, leading to decreased intracellular cAMP levels(By similarity). The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. Required for normal cytokinesis during mitosis(PubMed:17635935).

Molekulargewicht: 40 kDa

Gen-ID: 2770

UniProt: P63096

Pathways: G-protein mediated Events