CBFA2T3 Antikörper

Produktnummer ABIN7113057

Produktdetails anti-CBFA2T3 Antikörper

Target: CBFA2T3 (Core-binding Factor, Runt Domain, alpha Subunit 2, Translocated To, 3 (CBFA2T3))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CBFA2T3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Aufreinigung: Immunogen affinity purified

Reinheit: ≥95 % as determined by SDS-PAGE

Immunogen: core-binding factor, runt domain, alpha subunit 2, translocated to, 3

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:500-1:2000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Haltbarkeit: 12 months

Details zu CBFA2T3

Target: CBFA2T3 (Core-binding Factor, Runt Domain, alpha Subunit 2, Translocated To, 3 (CBFA2T3))

Andere Bezeichnung: CBFA2T3 (CBFA2T3 Produkte)

Synonyme: A630044F12Rik antikoerper, AI465270 antikoerper, AW229127 antikoerper, Cbfa2t3h antikoerper, ETO-2 antikoerper, Eto2 antikoerper, MTGR2 antikoerper, MTG16a antikoerper, MTG16b antikoerper, ETO2 antikoerper, MTG16 antikoerper, ZMYND4 antikoerper, core-binding factor, runt domain, alpha subunit 2, translocated to, 3 (human) antikoerper, CBFA2/RUNX1 translocation partner 3 antikoerper, Cbfa2t3 antikoerper, CBFA2T3 antikoerper

Hintergrund: Synonyms:MTG16, MTGR2, ZMYND4 Background:Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes(PubMed:12559562, PubMed:15203199). Can repress the expression of MMP7 in a ZBTB33-dependent manner(PubMed:23251453). Reduces the protein levels and stability of the transcriptinal regulator HIF1A, interacts with EGLN1 and promotes the HIF1A prolyl hydroxylation-dependent ubiquitination and proteasomal degradation pathway(PubMed:25974097). Contributes to inhibition of glycolysis and stimulation of mitochondrial respiration by down-regulating the expression of glycolytic genes including PFKFB3, PFKFB4, PDK1, PFKP, LDHA and HK1 which are direct targets of HIF1A(PubMed:23840896, PubMed:25974097). Regulates the proliferation and the differentiation of erythroid progenitors by repressing the expression of TAL1 target genes(By similarity). Plays a role in granulocyte differentiation(PubMed:15231665). Isoform 2 functions as an A-kinase-anchoring protein(PubMed:11823486).

Molekulargewicht: 62-65kd

Gen-ID: 863

UniProt: O75081