HPV16 E7 Antikörper (Alexa Fluor 750)

Produktnummer ABIN7091235

Produktdetails anti-HPV16 E7 Antikörper (Alexa Fluor 750)

Target: HPV16 E7 (HPV-16 E7) (Human Papilloma Virus 16 E7 (HPV-16 E7))

Reaktivität: Human Papillomavirus 16 (HPV-16), Virus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HPV16 E7 Antikörper ist konjugiert mit Alexa Fluor 750

Applikation: Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Kreuzreaktivität: Virus

Kreuzreaktivität (Details): HPV16

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from HPV16 E7 protein

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF(IHC-P) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Details zu HPV16 E7

Target: HPV16 E7 (HPV-16 E7) (Human Papilloma Virus 16 E7 (HPV-16 E7))

Andere Bezeichnung: HPV16 E7 (HPV-16 E7 Produkte)

Synonyme: transforming protein E7 antikoerper, E7 antikoerper

Substanzklasse: Viral Protein

Hintergrund:

Synonyms: E7, Human Papilloma Virus, Human papillomavirus type 16 E7, Human papillomavirus type 16 E7, Protein E7, Human Papillomavirus 16 E7, HPV16 E7, E7 protein HPV16, VE7_HPV16.

Background: Human papilloma viruses (HPVs) can be classified as either high risk or low risk according to their association with cancer. HPV16 and HPV18 are the most common of the high risk group while HPV6 and HPV11 are among the low risk types. Approximately 90 % of cervical cancers contain HPV DNA of the high risk types. Mutational analysis have shown that the E6 and E7 genes of the high risk HPVs are necessary and sufficient for HPV transforming function. The specific interactions of the E6 and E7 proteins with p53 and pRB, respectively, correlate with HPV high and low risk classifications. The high risk HPV E7 proteins bind to pRB with a higher affinity than do the low risk HPV proteins, and only the high risk HPV E6 proteins form detectable complexes with p53 in vitro.

Gen-ID: 1489079