TSC1 Antikörper (AA 131-230)

Produktnummer ABIN704846

Produktdetails anti-TSC1 Antikörper

Target: TSC1 (Tuberous Sclerosis 1 (TSC1))

Bindungsspezifität: AA 131-230

Reaktivität: Schaf

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TSC1 Antikörper ist unkonjugiert

Applikation: ELISA, Western Blotting (WB)

Kreuzreaktivität: Schaf

Homologie: Human,Mouse,Rat,Dog,Cow,Pig,Horse

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Hamartin

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
ELISA 1:500-1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Referenzen für anti-TSC1 Antikörper (ABIN704846)

Cao, Wei, Liu, Wang, Wu, Xie, Capellini, Zhang, Zhao, Li, Zhong, Wang, Lu, Liu, Zhang, Du, Zhang, Du: "DNA methylation Landscape of body size variation in sheep." in: Scientific reports, Vol. 5, pp. 13950, (2016) (PubMed).

Details zu TSC1

Target: TSC1 (Tuberous Sclerosis 1 (TSC1))

Andere Bezeichnung: Hamartin/TSC1 (TSC1 Produkte)

Synonyme: LAM antikoerper, TSC antikoerper, hamartin antikoerper, mKIAA0243 antikoerper, tsc1 antikoerper, wu:fc38b04 antikoerper, fa99f04 antikoerper, wu:fa99f04 antikoerper, zgc:63657 antikoerper, TSC complex subunit 1 antikoerper, tuberous sclerosis 1 antikoerper, TSC complex subunit 1b antikoerper, TSC complex subunit 1a antikoerper, TSC1 antikoerper, Tsc1 antikoerper, tsc1b antikoerper, tsc1 antikoerper, tsc1a antikoerper

Hintergrund:

Synonyms: LAM, TSC1, Tuberous sclerosis 1 protein, TSC1_HUMAN.

Background: Hamartin, or TSC1, is a suspected tumor suppressor implicated in the disease tuberous sclerosis 1. It is a negative regulator of cell division controlling the transition from G0/G1 to S phase, and it seems to act through the phosphatidylinositol 3 kinase/Akt pathway. TSC1 interacts with tuberin m(TSC2), which is thought to be a GAP (GTPase Activating Protein) for the Rap1 and Rab5 small G Proteins. The Hamartin/Tuberin complex has been shown to inhibit mTor. Hamartin has also been shown to interact with ERM (Ezrin-Radixin-Moesin) proteins and with F-actin, suggesting a role for TSC proteins in modulation of cell adhesion and morphology.

Gen-ID: 7248

UniProt: Q92574

Pathways: RTK Signalweg, AMPK Signaling, Regulation of Cell Size, Tube Formation