TOP3A Antikörper

Produktnummer ABIN7075939

Produktdetails anti-TOP3A Antikörper

Target: TOP3A (Topoisomerase (DNA) III alpha (TOP3A))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TOP3A Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Kreuzreaktivität: Human

Aufreinigung: Affinity purification

Immunogen: KLH conjugated Synthetic peptide corresponding to Mouse Topoisomerase III alpha

Anwendungsinformationen

Applikationshinweise: WB (H) 1:500-1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS, pH 7.4, 0.02 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Details zu TOP3A

Target: TOP3A (Topoisomerase (DNA) III alpha (TOP3A))

Andere Bezeichnung: Topoisomerase III alpha (TOP3A Produkte)

Synonyme: TOP3 antikoerper, DNA topoisomerase III alpha antikoerper, topoisomerase (DNA) III alpha antikoerper, Top3a antikoerper, TOP3A antikoerper

Hintergrund: DNA topoisomerase 3-alpha (TOP3A) is an essential component of the RMI complex, a complex involves in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. It releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand than undergoes passage around the unbroken strand thus removing DNA supercoils.

Molekulargewicht: 112 kDa

Gen-ID: 21975

NCBI Accession: NP_033436

UniProt: O70157

Pathways: DNA Reparatur