GDN antikoerper, GDNPF antikoerper, PI-7 antikoerper, PI7 antikoerper, PN-1 antikoerper, PN1 antikoerper, PNI antikoerper, SERPINE2 antikoerper, MGC143011 antikoerper, Gdnpn1 antikoerper, Pn-1 antikoerper, Spin4 antikoerper, B230326M24Rik antikoerper, PAI-1 antikoerper, Spi4 antikoerper, zgc:55929 antikoerper, serpin family E member 2 antikoerper, serine (or cysteine) peptidase inhibitor, clade E, member 2 antikoerper, serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 antikoerper, SERPINE2 antikoerper, serpine2 antikoerper, Serpine2 antikoerper
Hintergrund
The serine protease inhibitors (serpins) compose a superfamily of proteins with a diverse set of functions, including the control of blood coagulation, complement activation, programmed cell death and development. Serpins are secreted glycoproteins that contain a stretch of peptide that mimics a true substrate for a corresponding serine protease. Protease nexin-1 (PN-1) is a serpin that inactivates several proteases, including thrombin, urokinase, plasminogen activators (PA) and plasmin. It is involved in tissue remodeling, cellular invasiveness, matrix degradation and tumor growth.