PKD1 Antikörper

Produktnummer ABIN7075124

Produktdetails anti-PKD1 Antikörper

Target: PKD1 (Polycystic Kidney Disease 1 (Autosomal Dominant) (PKD1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PKD1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Kreuzreaktivität: Human

Aufreinigung: Affinity purification

Immunogen: Recombinant protein corresponding to Mouse Polycystin 1

Anwendungsinformationen

Applikationshinweise: WB (H) 1: 500-1: 1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS, pH 7.4, 0.02 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Details zu PKD1

Target: PKD1 (Polycystic Kidney Disease 1 (Autosomal Dominant) (PKD1))

Andere Bezeichnung: Polycystin 1 (PKD1 Produkte)

Synonyme: PBP antikoerper, Pc-1 antikoerper, TRPP1 antikoerper, PC1 antikoerper, mFLJ00285 antikoerper, polycystin 1, transient receptor potential channel interacting antikoerper, polycystin 1, transient receptor poteintial channel interacting antikoerper, polycystin-1 antikoerper, PKD1 antikoerper, Pkd1 antikoerper, LOC749291 antikoerper

Hintergrund: This gene encodes a member of the polycystin protein family. The encoded glycoprotein contains a large N-terminal extracellular region, multiple transmembrane domains and a cytoplasmic C-tail. It is an integral membrane protein that functions as a regulator of calcium permeable cation channels and intracellular calcium homoeostasis. It is also involved in cell-cell/matrix interactions and may modulate G-protein-coupled signal-transduction pathways. Involved in renal tubulo genesis. Involved in fluid-flow mechano sensation by the primary cilium in renal epithelium (By similarity). Acts as a regulator of cilium length, together with PKD2 (By similarity). and mutations in this gene cause autosomal dominant polycystic kidney disease type 1 (ADPKD1). ADPKD1 is characterized by the growth of fluid-filled cysts that replace normal renal tissue and result in end-stage renal failure. Splice variants encoding different isoforms have been noted for this gene.

Molekulargewicht: >460 kDa

Gen-ID: 18763

NCBI Accession: NP_038658

UniProt: O08852

Pathways: Myometrial Relaxation and Contraction, Maintenance of Protein Location