KIAA1524 Antikörper

Produktnummer ABIN7074432

Produktdetails anti-KIAA1524 Antikörper

Target: KIAA1524

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser KIAA1524 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Kreuzreaktivität: Human, Ratte

Aufreinigung: Affinity purification

Immunogen: Recombinant protein corresponding to Mouse CIP2A

Anwendungsinformationen

Applikationshinweise: WB (H,M,R) 1:500-1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS, pH 7.4, 0.02 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Details zu KIAA1524

Target: KIAA1524

Andere Bezeichnung: CIP2A (KIAA1524 Produkte)

Synonyme: CIP2A antikoerper, p90 antikoerper, AA408511 antikoerper, AU018569 antikoerper, Cip2a antikoerper, Kiaa1524 antikoerper, KIAA1524 antikoerper, LOC100222895 antikoerper, RGD1310335 antikoerper, cell proliferation regulating inhibitor of protein phosphatase 2A antikoerper, RIKEN cDNA C330027C09 gene antikoerper, KIAA1524 antikoerper, cell proliferation regulating inhibitor of protein phosphatase 2A L homeolog antikoerper, CONSTANS interacting protein 2a antikoerper, CIP2A antikoerper, C330027C09Rik antikoerper, KIAA1524 antikoerper, cip2a.L antikoerper, CIP2a antikoerper, cip2a antikoerper, Cip2a antikoerper

Hintergrund: Inhibition of protein phosphatase 2A (PP2A) activity has been identified as a prerequisite for the transformation of human cells. The protein, designated Cancerous Inhibitor of PP2A (CIP2A), interacts directly with the oncogenic transcription factor c-Myc, inhibits PP2A activity toward c-Myc serine 62 (S62), and thereby prevents c-Myc proteolytic degradation. In addition to its function in c-Myc stabilization, CIP2A promotes anchorage-independent cell growth and in vivo tumor formation. The oncogenic activity of CIP2A is demonstrated by transformation of human cells by overexpression of CIP2A. Importantly, CIP2A is overexpressed in two common human malignancies, head and neck squamous cell carcinoma (HNSCC) and colon cancer.

Molekulargewicht: 102 kDa

Gen-ID: 224171

NCBI Accession: NP_766204

UniProt: Q8BWY9