KCNAB2 Antikörper (AA 20-34)

Produktnummer ABIN7043512

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch KCNAB2 in WB, IHC, IF und IC. Es zeigt Reaktivität gegenüber Proben von Ratte.

Kurzübersicht für KCNAB2 Antikörper (AA 20-34) (ABIN7043512)

Target: KCNAB2 (Potassium Voltage-Gated Channel, Shaker-Related Subfamily, beta Member 2 (KCNAB2))

Reaktivität: Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser KCNAB2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunochromatography (IC)

Produktdetails anti-KCNAB2 Antikörper

Bindungsspezifität: AA 20-34

Verwendungszweck: A Rabbit Polyclonal Antibody to KV?2 Subunit

Spezifität: N-terminal domain

Kreuzreaktivität: Human, Maus, Ratte

Homologie: Mouse,human,rabbit - identical

Produktmerkmale: Anti-Kvbeta2 Antibody is directed against an epitope of rat KVβ2. Anti-KVβ2 Antibody (ABIN7043512 and ABIN7045014) can be used in western blot, immunohistochemistry and immunocytochemistry applications. It has been designed to recognize KVβ2 from rat, mouse and human samples.

Aufreinigung: Affinity purified on immobilized antigen.

Immunogen:

Immunogen: Synthetic peptide

Immunogen Sequence: SPGMIYSTRYGSPKR(C), corresponding to amino acid residues 20-34 of rat KCNAB2 

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

Antigen preadsorption control: 1 μg peptide per 1 μg antibody

Application Dilutions Immunohistochemistry paraffin embedded sections ihc: N/A

Application Dilutions Western blot wb: 1:200

Kommentare:

Cited Application: IP

Negative Control: (ABIN7236472)

Blocking Peptide: (ABIN7236472)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Recosntitute with double distilled water (DDW) to a concentration of 1.0 mg/mL.

Konzentration: 1 mg/mL

Buffer: PBS pH 7.4

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung:

Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.

Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

Details zu KCNAB2

Target: KCNAB2 (Potassium Voltage-Gated Channel, Shaker-Related Subfamily, beta Member 2 (KCNAB2))

Andere Bezeichnung: KCNAB2

Hintergrund: Voltage-gated potassium channel subunit beta-2, KV beta 2, KCNAB2, Ckbeta2,KVβ2 (or KCNAB2) is a member of a family of proteins that regulate the activity of voltage-dependent K+ channels. The other members of the family are KVβ1 and KVβ3.The KVβ subunits were originally identified using a biochemical approach that demonstrated that the ion-conducting α subunits existed in a macromolecular complex with auxiliary β subunits with a probable stoichiometry of α4β4. It is now widely established that the regulatory β subunits are able to alter both the biophysical (i.e. acceleration of inactivation kinetics) and biochemical (promote cell surface expression) properties of the functional KV channel.The KVβ regulatory subunits are cytosolic proteins with conserved C-termini and variable N-terminus domains. The interaction with the α subunits is via the conserved C-terminus that binds to a specific sequence in the N-terminus of the α subunits.KVβ2, as well as the other KVβ subunits can bind to all the members of the large KV1.x (Shaker) channel subfamily. However, recent evidence suggests that it can also bind to members of the KV4.x subfamily.KVβ2 is the most abundant β subunit in the brain, where it couples with all the KV1.x subunits, but the protein is also expressed in peripheral tissues including the heart, lungs and cells of hematopoietic origin such as T cells where it couples with KV1.3, the dominant voltage-dependent K+ channel in these cells.

Alternative names: KVbeta2, Voltage-gated potassium channel subunit beta-2, KV beta 2, KCNAB2, Ckbeta2

Gen-ID: 29738

NCBI Accession: NM_172130

UniProt: P62483