FBXW4 Antikörper

Produktnummer ABIN7264203

Produktdetails anti-FBXW4 Antikörper

Target: FBXW4 (F-Box and WD Repeat Domain Containing 4 (FBXW4))

Reaktivität: Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FBXW4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktmerkmale: Polyclonal Antibody

Aufreinigung: Affinity purification

Immunogen: Recombinant fusion protein of human FBXW4 (NP_071322.1).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:2000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu FBXW4

Target: FBXW4 (F-Box and WD Repeat Domain Containing 4 (FBXW4))

Andere Bezeichnung: FBXW4 (FBXW4 Produkte)

Synonyme: dac antikoerper, hag antikoerper, hagoromo antikoerper, wu:fk63g06 antikoerper, FBXW4 antikoerper, DAC antikoerper, FBW4 antikoerper, FBWD4 antikoerper, SHFM3 antikoerper, SHSF3 antikoerper, Dac antikoerper, Fbw4 antikoerper, dactylin antikoerper, dactylyn antikoerper, F-box and WD repeat domain containing 4 antikoerper, F-box and WD-40 domain protein 4 antikoerper, fbxw4 antikoerper, FBXW4 antikoerper, Fbxw4 antikoerper

Hintergrund: This gene is a member of the F-box/WD-40 gene family, which recruit specific target proteins through their WD-40 protein-protein binding domains for ubiquitin mediated degradation. In mouse, a highly similar protein is thought to be responsible for maintaining the apical ectodermal ridge of developing limb buds, disruption of the mouse gene results in the absence of central digits, underdeveloped or absent metacarpal/metatarsal bones and syndactyly. This phenotype is remarkably similar to split hand-split foot malformation in humans, a clinically heterogeneous condition with a variety of modes of transmission. An autosomal recessive form has been mapped to the chromosomal region where this gene is located, and complex rearrangements involving duplications of this gene and others have been associated with the condition. A pseudogene of this locus has been mapped to one of the introns of the BCR gene on chromosome 22.

Molekulargewicht:

Observed_MW: 46 kDa

Calculated_MW: 46 kDa

Gen-ID: 6468

UniProt: P57775