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PDHX Antikörper

PDHX Reaktivität: Human, Maus, Ratte IF Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN7262258
  • Target Alle PDHX Antikörper anzeigen
    PDHX (Pyruvate Dehydrogenase Complex, Component X (PDHX))
    Reaktivität
    Human, Maus, Ratte
    Wirt
    • 34
    • 3
    • 1
    • 1
    Kaninchen
    Klonalität
    • 38
    • 1
    Polyklonal
    Konjugat
    • 18
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser PDHX Antikörper ist unkonjugiert
    Applikation
    • 31
    • 13
    • 13
    • 7
    • 7
    • 5
    • 5
    • 3
    • 3
    • 2
    • 1
    • 1
    Immunofluorescence (IF)
    Produktmerkmale
    Polyclonal Antibody
    Aufreinigung
    Affinity purification
    Immunogen
    Recombinant fusion protein of human PDHX (NP_003468.2).
    Isotyp
    IgG
    Top Product
    Discover our top product PDHX Primärantikörper
  • Applikationshinweise
    IF 1:10-1:100
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C. Avoid freeze / thaw cycles.
  • Target
    PDHX (Pyruvate Dehydrogenase Complex, Component X (PDHX))
    Andere Bezeichnung
    PDHX (PDHX Produkte)
    Synonyme
    DLDBP antikoerper, E3BP antikoerper, OPDX antikoerper, PDX1 antikoerper, proX antikoerper, AI481367 antikoerper, E3bp antikoerper, Pdx1 antikoerper, Ac1164 antikoerper, zgc:66110 antikoerper, zgc:85977 antikoerper, MGC86218 antikoerper, PDHX antikoerper, DDBDRAFT_0168431 antikoerper, DDBDRAFT_0230192 antikoerper, DDB_0168431 antikoerper, DDB_0230192 antikoerper, pyruvate dehydrogenase complex component X antikoerper, pyruvate dehydrogenase complex, component X antikoerper, pyruvate dehydrogenase complex component X L homeolog antikoerper, E3-binding protein antikoerper, PDHX antikoerper, Pdhx antikoerper, pdhx antikoerper, pdhx.L antikoerper, pdhX antikoerper
    Hintergrund
    The pyruvate dehydrogenase (PDH) complex is located in the mitochondrial matrix and catalyzes the conversion of pyruvate to acetyl coenzyme A. The PDH complex thereby links glycolysis to Krebs cycle. The PDH complex contains three catalytic subunits, E1, E2, and E3, two regulatory subunits, E1 kinase and E1 phosphatase, and a non-catalytic subunit, E3 binding protein (E3BP). This gene encodes the E3 binding protein subunit, also known as component X of the pyruvate dehydrogenase complex. This protein tethers E3 dimers to the E2 core of the PDH complex. Defects in this gene are a cause of pyruvate dehydrogenase deficiency which results in neurological dysfunction and lactic acidosis in infancy and early childhood. This protein is also a minor antigen for antimitochondrial antibodies. These autoantibodies are present in nearly 95 % of patients with the autoimmune liver disease primary biliary cirrhosis (PBC). In PBC, activated T lymphocytes attack and destroy epithelial cells in the bile duct where this protein is abnormally distributed and overexpressed. PBC eventually leads to cirrhosis and liver failure. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
    Gen-ID
    8050
    UniProt
    O00330
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