NUDT1 Antikörper

Produktnummer ABIN7256838

Produktdetails anti-NUDT1 Antikörper

Target: NUDT1 (Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 1 (NUDT1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NUDT1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Spezifität: This antibody ist KO validated.

Produktmerkmale: Polyclonal Antibody

Aufreinigung: Affinity purification

Güteklasse: KO Validated

Immunogen: Recombinant fusion protein of human NUDT1 (NP_945192.1).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:2000 IHC 1:50-1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu NUDT1

Target: NUDT1 (Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 1 (NUDT1))

Andere Bezeichnung: NUDT1 (NUDT1 Produkte)

Synonyme: mutT antikoerper, nudT1 antikoerper, MTH1 antikoerper, Mth1 antikoerper, 7,8-dihydro-8-oxoguanine triphosphatase antikoerper, nudix hydrolase 1 antikoerper, nudix (nucleoside diphosphate linked moiety X)-type motif 1 antikoerper, mth1 antikoerper, Tsp_07498 antikoerper, nudt1 antikoerper, 8odp antikoerper, NUDT1 antikoerper, Nudt1 antikoerper

Hintergrund: Misincorporation of oxidized nucleoside triphosphates into DNA/RNA during replication and transcription can cause mutations that may result in carcinogenesis or neurodegeneration. The protein encoded by this gene is an enzyme that hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP, 8-oxo-dATP, 2-hydroxy-dATP, and 2-hydroxy rATP, to monophosphates, thereby preventing misincorporation. The encoded protein is localized mainly in the cytoplasm, with some in the mitochondria, suggesting that it is involved in the sanitization of nucleotide pools both for nuclear and mitochondrial genomes. Several alternatively spliced transcript variants, some of which encode distinct isoforms, have been identified. Additional variants have been observed, but their full-length natures have not been determined. A single-nucleotide polymorphism that results in the production of an additional, longer isoform (p26) has been described.

Molekulargewicht:

Observed_MW: 18 kDa

Calculated_MW: 17 kDa/19 kDa/20 kDa/22 kDa

Gen-ID: 4521

UniProt: P36639