HLA-DQB2 Antikörper

Produktnummer ABIN7253932

Produktdetails anti-HLA-DQB2 Antikörper

Target: HLA-DQB2 (Major Histocompatibility Complex, Class II, DQ beta 2 (HLA-DQB2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HLA-DQB2 Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (IHC)

Produktmerkmale: Polyclonal Antibody

Aufreinigung: Antigen affinity purification

Immunogen: Fusion protein of human HLA-DQB2

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IHC 1:50-1:200, ELISA 1:5000-1:10000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1.26 mg/mL

Buffer: PBS with 0.05 % Sodium azide and 40 % Glycerol, pH 7.4

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu HLA-DQB2

Target: HLA-DQB2 (Major Histocompatibility Complex, Class II, DQ beta 2 (HLA-DQB2))

Andere Bezeichnung: HLA-DQB2 (HLA-DQB2 Produkte)

Synonyme: HLA-DQB1 antikoerper, HLA-DXB antikoerper, major histocompatibility complex, class II, DQ beta 2 antikoerper, HLA-DQB2 antikoerper

Hintergrund: HLA-DQB2 belongs to the family of HLA class II beta chain paralogs. Class II molecules are heterodimers consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. They play a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). Polymorphisms in the alpha and beta chains specify the peptide binding specificity, and typing for these polymorphisms is routinely done for bone marrow transplantation. However this gene, HLA-DQB2, is not routinely typed, as it is not thought to have an effect on transplantation. There is conflicting evidence in the literature and public sequence databases for the protein-coding capacity of HLA-DQB2. Because there is evidence of transcription and an intact ORF, HLA-DQB2 is represented in Entrez Gene and in RefSeq as a protein-coding locus.

UniProt: P05538

Pathways: T-Zell Rezeptor Signalweg