CHRDL2 Antikörper

Produktnummer ABIN7238816

Produktdetails anti-CHRDL2 Antikörper

Target: CHRDL2 (Chordin-Like 2 (CHRDL2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CHRDL2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktmerkmale: Polyclonal Antibody

Aufreinigung: Affinity purification

Immunogen: Synthetic peptide of human CHRDL2

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:2000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.3 mg/mL

Buffer: PBS with 0.05 % sodium azide and 50 % glycerol, PH7.4

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu CHRDL2

Target: CHRDL2 (Chordin-Like 2 (CHRDL2))

Andere Bezeichnung: CHRDL2 (CHRDL2 Produkte)

Synonyme: BNF1 antikoerper, CHL2 antikoerper, FKSG37 antikoerper, 1810022C01Rik antikoerper, Chl2 antikoerper, chl antikoerper, si:dkey-11j5.7 antikoerper, si:dkey-11j5.7-like antikoerper, chordin like 2 antikoerper, chordin-like 2 antikoerper, CHRDL2 antikoerper, Chrdl2 antikoerper, chrdl2 antikoerper

Hintergrund: CHRDL2 (chordin-related protein 2), also known as BNF1 (breast tumor novel factor 1) or CHL2 (chordin-like 2), is a 429 amino acid protein that belongs to the chordin family of proteins. CHRDL2 contains three VWFC (von Willebrand Factor type C) domains and is predominantly expressed in uterus and moderately expressed in prostate, liver, ovary, heart and testis. Due to alternative splicing events, CHRDL2 exists as five isoforms, namely isoform I, isoform II, isoform VII, isoform VIII and isoform IX. Two of these isoforms are secreted, while the other three localize to the cytoplasm. Functioning as a BMP-binding inhibitor, CHRDL2 directly interacts with BMPs and blocks their binding to BMP receptors, thereby inhibiting BMP activity. In breast, lung and colon tumors, CHRDL2 expression is upregulated, suggesting a possible role in tumorigenesis.

Molekulargewicht: 48 kDa

NCBI Accession: NP_056239

UniProt: Q6WN34