VISTA Antikörper (C-Term)

Produktnummer ABIN6992209

Produktdetails anti-VISTA Antikörper

Target: VISTA (V-type immunoglobulin domain-containing suppressor of T-cell activation (VISTA))

Bindungsspezifität: C-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser VISTA Antikörper ist unkonjugiert

Applikation: ELISA, Western Blotting (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF)

Aufreinigung: VISTA Antibody is affinity chromatography purified via peptide column.

Immunogen: VISTA antibody was raised against a peptide corresponding to 15 amino acids near the carboxy terminus of human VISTA. The immunogen is located within the last 60 amino acids of VISTA.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: VISTA antibody can be used for Immunohistochemistry at 2 μ,g/mL. For Immunoflorescence start at 20 μ,g/mL. For Immunocytochemistry start at 1 μ,g/mL.

Antibody validated: Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: VISTA Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: VISTA antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu VISTA

Target: VISTA (V-type immunoglobulin domain-containing suppressor of T-cell activation (VISTA))

Andere Bezeichnung: VISTA (VISTA Produkte)

Synonyme: MGC112715 antikoerper, MGC151567 antikoerper, B7-H5 antikoerper, B7H5 antikoerper, GI24 antikoerper, PP2135 antikoerper, SISP1 antikoerper, Dies1 antikoerper, VISTA antikoerper, V-set immunoregulatory receptor antikoerper, vsir antikoerper, Vsir antikoerper, VSIR antikoerper

Hintergrund: The lymphocyte activation gene-3 (LAG3) is a member of the immunoglobulin superfamily and binds MHC class II with high affinity (1), negatively regulating T-cell function and homeostasis (2). It is expressed in B, T, and NK cells, monocytes, and dendritic cells (3), and acts to regulate T cell expansion (4). LAG3 is also an important immune checkpoint protein, with anti-LAG3 antibodies activating T effector cells and affecting regulatory T cell functions. Furthermore LAG3 appears to act in a synergistic fashion with PD-1/PD-L1, suggesting that a dual antibody approach may prove useful in cancer immunotherapy (5).

Gen-ID: 64115

NCBI Accession: NP_071436

UniProt: Q9H7M9

Pathways: Cancer Immune Checkpoints